Sex differences in learning and its mechanism

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It has been shown that there is a sex difference in learning process in animals. Even in human, men are superior in mathematic ability and women are better in words communication process. The present study was undertaken to proof the concept that there is a sex difference in the learning process in rats. Since the hippocampus plays a central role in this process, we analyzed the changes in hippocampal functions by behavioral, electrophysiological and biochemical methods. As the results, we revealed that estrogen plays a role for learning process by changes AMPA receptor subunit GluR1 function, which is critical for hippocampal learning ability.