Significance of chymase inhibition to prevent the complication of metabolic syndrome

在非酒精性脂肪性肝炎（NASH）和易卒中的自发性高血压（SHR-SP）大鼠作为代谢综合征并发症的动物模型上评价糜酶抑制剂的作用。在仓鼠NASH模型中，糜蛋白酶抑制剂改善了AST和ALT的血浆水平，并且还观察到脂质沉积和纤维化的改善。在SHR-SP大鼠中，糜酶抑制剂通过抗氧化作用和抑制炎性细胞向内皮细胞的浸润而抑制血管内皮功能障碍，但无明显的水肿作用。糜酶抑制剂也延长了生存期，提示糜酶抑制剂是预防代谢综合征并发症的有效策略。

Effects of the chymase inhibitor were evaluated on animal models with the non-alcoholic steatohepatitis (NASH) and stroke-prone spontaneously hypertensive (SHR-SP) rats as complications of the metabolic syndrome. In a hamster NASH model, plasma levels of AST and ALT were improved by the chymase inhibitor and the improvement of lipid deposition and fibrosis was also observed. In SHR-SP rats, the chymase inhibitor showed to prevent the vascular endothelial dysfunction via the anti-oxidative effect and the prevention of inflammatory cell-infiltration into the endothelium without hypotensive effect. The chymase inhibitor also extended the survival term.These results suggest that chymase inhibition become the useful strategy to prevent the complication of metabolic syndrome.