Elucidation of the regulatory mechanism for claudin-5 expression in vascular endothelial cells

点击翻译按钮获取中文摘要

Tissue hypoxia is known to accelerate the progression of intractable neural diseases through the breakdown of neural vascular barrier including the blood-brain barrier and the inner blood-retinal barrier. However, the mechanisms underlying the hypoxia-induced breakdown of vascular barrier remain unclarified. Here, using the in vitro and in vivo models of neural vascular barrier, we have specified two molecules, M1 and M2, as the indispensable molecules for hypoxia-induced breakdown of neural vascular barrier, and therefore the candidate molecules for new therapeutic targets of intractable neural diseases.