receptor

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Cytotoxic T cells against M. tuberculosis are one of most important immune cells for the protection of tuberculosis infection in human.(1)It was demonstrated first that HSP65 DNA+IL-12 DNA vaccine (HSP65 vaccine) and 15K Granulysin vaccine exerted the activity of cytotoxic T cell differentiation factor in the present study. (2)Therefore, the presence of the receptor for granulysin was strongly suggested. We are now isolating the granulysin receptor. (3)We found granulysin-granulysin positive feedback loop. Granulysin was produced from CTL, and granulysin act on the differentiation of CTL. (4)HSP65 vaccine and Granulysin vaccine exerted synergistic therapeutic efficacy against TB infection in mice, and showed the synergistic differentiation of CTL.