Clinicopathological study on adenocarcinoma of gastric phenotype and its precursor lesion

胰腺导管内乳头状黏液性肿瘤(IPMN)是一种主胰管和/或分支胰管产生粘蛋白的肿瘤。为了评估不同IPMN亚型之间的差异，对33例手术治疗的IPMN进行了胃肠细胞的免疫组织化学标记。IPMN分为胃型17例，肠型8例，胃肠型混合型7例，混合型1例。这些类型之间在年龄和性别上没有差异。胃幽门分化和小肠分化分别是胃型和肠型IPMN的特征，这两种IPMN可能有不同的发病机制。

Pancreatic intraductal papillary mucinous neoplasms (IPMNs) are mucin-producingneoplasms of the main and/or branch pancreatic ducts. To assess differences between various IPMN subtypes, immunohistochemical markers of gastrointestinal cells were evaluated in 33 surgically treated IPMNs. IPMNs into gastric (n=17), intestinal (n=8) and mixed gastric and intestinal type (collision=7, composite=1). No differences in age or sex were observed among these types. Gastric pyloric and small intestinal differentiation are characteristic of gastric and intestinal type IPMN, respectively, and these two IPMN types may have distinct pathogenesis.