Pathophysiological and pharmacological assessment of synaptic transmission in chronic pain states

慢性疼痛状态下突触传递的病理生理学和药理学评估

• 批准号: 23590720
• 负责人: TANABE Mitsuo
• 金额: $ 3.33万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590720/
• 关键词: 神経障害性疼痛; シナプス伝達; 脊髄スライス; パッチクランプ; グリシントランスポーター; C-線維誘発性フィールド電位; ドネペジル; ミルナシプラン; 下行性疼痛抑制機構; オキシトシン; 一酸化窒素; 認知機能

In chronic pain conditions including neuropathic and inflammatory pain, enhanced efficacy of synaptic transmission in the spinal dorsal horn contributes largely to hyperalgesia and tactile allodynia. Moreover, patients with chronic pain frequently express various symptoms of neuropsychologic impairment, including chronic fatigue, depression, anxiety, sleep disturbance and cognitive deficits, which further affects quality of life. In the study presented here, in particular focusing on monoamines, glycine and acetylcholine, behavioral studies as well as in vivo and in vitro electrophysiological studies were made to explore pathophysiology of neuropathic pain and the effects of some potentially analgesic drugs, which we consider is important to obtain crucial information for developing novel analgesic drugs to treat patients with chronic pain.

在包括神经性疼痛和炎性疼痛的慢性疼痛病症中，脊髓背角中突触传递的增强的功效在很大程度上促成痛觉过敏和触觉异常性疼痛。此外，慢性疼痛患者经常表现出各种神经心理障碍症状，包括慢性疲劳、抑郁、焦虑、睡眠障碍和认知缺陷，这进一步影响了生活质量。本研究以单胺类、甘氨酸和乙酰胆碱为主要研究对象，通过行为学研究、体内外电生理研究，探讨了神经病理性疼痛的病理生理机制以及一些潜在的镇痛药物的作用，为开发新型镇痛药物治疗慢性疼痛提供了重要信息。

项目成果

Further investigation of the effect of milnaciplan, a serotonin and noradrenaline reuptake inhibitor, on C-fiber-evoked field potentials in spinal long-term potentiation

进一步研究米那普兰（一种血清素和去甲肾上腺素再摄取抑制剂）对脊髓长时程增强中 C 纤维诱发场电位的影响

• 发表时间: 2012
• 作者: 田辺光男;大波壮一郎;小川公一;加藤晃;小野秀樹
• 通讯作者: 小野秀樹

Electrophysiological Evaluation of Pathophysiological and Pharmacological Characteristics of Chronic Pain

慢性疼痛病理生理学和药理学特征的电生理学评价

• DOI: 10.1248/yakushi.13-00236-5
• 发表时间: 2014
• 期刊: YAKUGAKU ZASSHI
• 影响因子: 0.3
• 作者: 桑名俊一;原田尚子;角友起;齋藤基一郎;小池和子;本田岳夫;仲嶋一範;Tanabe M
• 通讯作者: Tanabe M

Modulation of glycinergic synaptic transmission by blockade of glycine uptake in spinal superficial dorsal horn neurons of adult mice

通过阻断成年小鼠脊髓浅表背角神经元的甘氨酸摄取来调节甘氨酸突触传递

• 发表时间: 2012
• 作者: 倉岡聖也;小野秀樹;田辺光男
• 通讯作者: 田辺光男

Increased hippocampal glycine uptake and cognitive dysfunction after peripheral nerve injury

• DOI: 10.1016/j.pain.2010.12.029
• 发表时间: 2011-04
• 期刊: PAIN®
• 作者: D. Kodama;H. Ono;M. Tanabe

Effect of milnacipran, a 5-HT and noradrenaline reuptake inhibitor, on C-fiber-evoked field potentials in spinal long-term potentiation and neuropathic pain

米那普仑（5-HT 和去甲肾上腺素再摄取抑制剂）对脊髓长时程增强和神经性疼痛中 C 纤维诱发场电位的影响

• 发表时间: 2012
• 期刊: Be J Pharmacol
• 作者: 大波壮一郎;加藤晃;小川公一;篠原俊次;小野秀樹;田辺光男
• 通讯作者: 田辺光男