Chronic kidney disease, thyroid dysfunction and cardiovascular risk

慢性肾病、甲状腺功能障碍和心血管风险

• 批准号: 23590819
• 负责人: SAKURAI Masaru
• 金额: $ 3.33万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590819/
• 关键词: 疫学; 生活習慣病; 内分泌学

This study investigated the association between chronic kidney disease, thyroid dysfunction and cardiovascular risk factors in Japanese men and women.In a cross-sectional analyses, thyroid stimulating hormone (TSH) were related to the estimated glomerular filtration ratio (eGFR) (r=-0.125, p<0.001), and prevalence of thyroid dysfunction were higher in participants with low eGFR compared to those with normal eGFR.Changes in TSH levels during a 3-year follow-up were not associated with baseline eGFR. Baseline TSH levels were not associated with a 3-year changes in cardiovascular risk factors such as blood pressure and plasma lipid levels. However, decrease in HDL-cholesterol were significantly higher for participants with hypothyroidism accompanied by renal dysfunction compared to those with normal thyroid/renal function. These results suggest that hypothyroidism accompanied by the renal dysfunction may higher the risk of cardiovascular disease through the decrease in HDL-cholesterol.

本研究调查了日本男性和女性慢性肾脏疾病、甲状腺功能不全和心血管危险因素之间的关系，在横断面分析中，促甲状腺激素（TSH）与估计的肾小球滤过率（eGFR）相关。（r=-0.125，p <0.001），与eGFR正常的参与者相比，eGFR低的参与者甲状腺功能障碍的患病率更高。年随访与基线eGFR无关。基线TSH水平与心血管危险因素如血压和血脂水平的3年变化无关。然而，与甲状腺/肾功能正常的受试者相比，甲状腺功能减退伴肾功能不全的受试者的HDL-胆固醇降低显著更高。提示甲状腺功能减退伴肾功能不全可能通过降低HDL-胆固醇而增加心血管疾病的风险。

项目成果

Association between serum thyroid stimulating hormone within the normal range and indices of obesity in Japanese men and women

日本男性和女性血清促甲状腺激素正常范围与肥胖指数的关系

• 发表时间: 2014
• 期刊: Intern Med
• 作者: Sakurai M;Nakamura K;Miura K;Yoshita K;Takamura T;Nagasawa SY;Morikawa Y;Ishizaki M;Kido T;Naruse Y;Nakashima M;Nogawa N;Suwazono Y;Nakagawa H
• 通讯作者: Nakagawa H