Evaluation of human vascular wall tissue fragility

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With regard to more than 100 cases subjected to forensic autopsy between 2011-2013, gelatinase degrading activity was investigated in aorta, carotid and cerebral arteries and choroid plexus tissue samples in addition to serum and cerebrospinal fluid. In forensic autopsies of initially unidentified cases in which subsequently identity was established, aorta and coronary artery diffuse intimal thickening and tissue gelatinolytic activity were found to be useful in the determination of age. From the viewpoint of vascular wall tissue fragility, we histologically investigated the frequency of unexamined secondary aldosteronism, a cause of hypertension and recognized risk factor for vascular lesions, and based on our findings raised an alarm that sufficient attention is not being paid to this important issue. In animal experiments, based on the contention that vascular diffuse intimal thickening represents one type of fibrosis, analysis using an autoimmune disease model mouse was conducted.