Evaluation of human vascular wall tissue fragility

人体血管壁组织脆性评价

• 批准号: 23590844
• 负责人: ZUKA Masahiko
• 金额: $ 3.49万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590844/
• 关键词: 動脈硬化; プロテアーゼ; ゼラチナーゼ; 血管; 血管壁脆弱性; 病理組織学

With regard to more than 100 cases subjected to forensic autopsy between 2011-2013, gelatinase degrading activity was investigated in aorta, carotid and cerebral arteries and choroid plexus tissue samples in addition to serum and cerebrospinal fluid. In forensic autopsies of initially unidentified cases in which subsequently identity was established, aorta and coronary artery diffuse intimal thickening and tissue gelatinolytic activity were found to be useful in the determination of age. From the viewpoint of vascular wall tissue fragility, we histologically investigated the frequency of unexamined secondary aldosteronism, a cause of hypertension and recognized risk factor for vascular lesions, and based on our findings raised an alarm that sufficient attention is not being paid to this important issue. In animal experiments, based on the contention that vascular diffuse intimal thickening represents one type of fibrosis, analysis using an autoimmune disease model mouse was conducted.

关于2011-2013年间进行法医尸检的100多例病例，除血清和脑脊液外，还对主动脉、颈动脉、脑动脉和脉络丛组织样本中明胶酶降解活性进行了调查。在最初身份不明的病例的法医尸检中，随后确定了身份，发现主动脉和冠状动脉弥漫性内膜增厚和组织明胶溶解活性对确定年龄是有用的。从血管壁组织脆性的角度，我们从组织学的角度研究了未经检查的继发性醛固酮增多症的频率，这是高血压的一个原因，也是血管病变的公认危险因素，基于我们的发现，提出了一个警告，即没有对这一重要问题给予足够的重视。在动物实验中，基于血管弥漫性内膜增厚代表一种纤维化类型的论点，使用了一种自身免疫性疾病模型小鼠进行了分析。

项目成果

医事法学・法医学

医学法/法医学

• 发表时间: 2012
• 作者: 岡久美子;浅利優;大村友博;磯崎翔太郎;市丸千聖;吉田将亜;松原和夫;塩野寛;松田光悦;清水惠子;塚 正彦 他 編集：寺野彰・一杉正仁
• 通讯作者: 塚 正彦 他 編集：寺野彰・一杉正仁

Fatal and non-fatal cases of lime sulfide exposure and pathogenetic mechanisms underlying pancreatic injury : Case reports with an animal experiment

硫化石灰暴露的致命和非致命病例以及胰腺损伤的发病机制：动物实验病例报告

• DOI: 10.1016/j.jflm.2012.02.027
• 发表时间: 2012
• 期刊: J Forensic Leg Med
• 影响因子: 1.5
• 作者: Zuka M;Chinaka S;Matsumoto Y;Takayama N;Hitomi Y;Nakamura H;Ohshima T
• 通讯作者: Ohshima T

Tracheal injury added to cervical bone destruction due to the impact of hitting the water surface: four immersed adult bodies.

• DOI: 10.1016/j.forsciint.2013.02.009
• 发表时间: 2013-05
• 期刊: Forensic science international
• 影响因子: 2.2
• 作者: Masahiko Zuka;T. Ohshima

Inhibition of APRIL suppresses disease progression : Analysis from a novel mouse model for IgG4-realted disease

抑制 APRIL 可抑制疾病进展：对 IgG4 相关疾病的新型小鼠模型进行分析

• 发表时间: 2014
• 作者: Yamada K;Zuka M;Ito K;Suzuki Y;Kakuchi Y;Onoe T;Yamagishi M;Kawano M
• 通讯作者: Kawano M

副腎良性腫瘍を伴っていた自殺の2事例

两例与良性肾上腺肿瘤相关的自杀事件

• 发表时间: 2013
• 作者: 塚正彦;大島徹
• 通讯作者: 大島徹