Study on the Proportion of Intravenously Administered Drugs Excreted into the Stomach in Forensic Autopsy Cases

法医尸检案件中静脉给药药物排泄入胃的比例研究

• 批准号: 23590864
• 负责人: MORIYA Fumio
• 金额: $ 1.25万
• 依托单位: Kawasaki University of Medical Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590864/
• 关键词: 社会医学; 法中毒学; 静脈内投与薬物; 塩基性薬物; メタンフェタミン; 胃内分泌; ガスクロマトグラフィー; ガスクロマトグラフ-質量分析法; ガスクロマトブラフ‐質量分析法; 薬物分析; 静脈内投与; 医療処置; ガスクロマトグラフ-質量分析

I demonstrated that: (1) in both basic therapeutic agents that were intravenously administered during the course of unsuccessful medical treatments and intravenously self-administered methamphetamine, a relatively good positive correlation was observed between the levels of those substances in the blood and stomach contents; (2) the average stomach content-to-blood ratio was 9.59 for basic agents, 0.38 for acidic agents and 16.1 for methamphetamine; (3) up to 10 mg of methamphetamine can accumulate in the stomach; and (4) the stomach-to-blood methamphetamine ratio is significantly affected by the particular mechanism of death. The stomach content-to-blood ratio for basic drugs may serve as a criterion for discriminating whether a drug was administered orally or intravenously.

我证明了：（1）在不成功的医疗过程中静脉注射的基本治疗药物和静脉自行注射甲基苯丙胺中，血液和胃内容物中这些物质的水平之间观察到相对良好的正相关性;（2）胃含物与血液的平均比值：碱性物质为9.59，酸性物质为0.38，甲基苯丙胺为16.1;和（4）胃-血甲基苯丙胺比率受特定死亡机制的显著影响。基本药物的胃内容物与血液的比例可以作为区分药物是口服还是静脉给药的标准。

项目成果

死亡過程が静脈内投与されたメタンフェタミンの胃内容/血液濃度比に及ぼす影響

死亡过程对静脉注射甲基苯丙胺胃内容物/血液浓度比的影响。

• 发表时间: 2013
• 作者: 守屋文夫;吉留敬;宮石智
• 通讯作者: 宮石智

A large proportion of intravenously administered methamphetamine is excreted into the stomach

静脉注射的冰毒很大一部分被排泄到胃中

• 发表时间: 2014
• 期刊: Forensic Toxicology
• 影响因子: 2.2
• 作者: Fumio Moriya;Kei Yoshitome;Satoru Miyaishi
• 通讯作者: Satoru Miyaishi

静脈内投与されたメタンフェタミンは胃内に多量に排泄される

静脉注射的甲基苯丙胺会大量排泄到胃中。

• 发表时间: 2013
• 作者: 守屋文夫;吉留敬;宮石智
• 通讯作者: 宮石智

剖検試料の薬毒物分析の特殊性

尸检样本药物毒理学分析专业

• 发表时间: 2012
• 作者: 吉留敬;宮石智;守屋文夫
• 通讯作者: 守屋文夫

Excretion into the stomach of intravenously administered drugs used for medical treatment

用于治疗的静脉注射药物排泄到胃中

• 发表时间: 2012
• 作者: Terada M;Shinozuka T;Hasegawa C;Tanak E;Hayashida M;Ohno Y;Kurosaki K;Fumio Moriya
• 通讯作者: Fumio Moriya