Association between Helicobacter pylori infection and bronchial asthma

幽门螺杆菌感染与支气管哮喘的关系

• 批准号: 23590924
• 负责人: ARAKAWA Tetsuo
• 金额: $ 3.24万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590924/
• 关键词: ヘリコバクター・ピロリ; 気管支喘息; 喘息; ヘリコバクター; ヘリコバクターピロリ

Helicobacter pylori infection is pathogens associated with gastritis, peptic ulcers, and gastric cancer. However, epidemiological studies showed a negative association between H. pylori infection and development of bronchial asthma. The aim of the present project was to determine whether H. pylori infection affects development of bronchial asthma in an animal model. We examined effect of H. pylori infection on severity of ovalbumin- induced asthma in Mongolian gerbil. Ovalbumin induced similar severity of asthma, infiltration of inflammatory cells, cytokines, histological changes in both H. pylori infected and non-infected mice. H. pylori infection might not be associated with development of bronchial asthma.

幽门螺杆菌感染是与胃炎、消化性溃疡和胃癌相关的病原体。然而，流行病学研究表明，幽门螺杆菌感染与支气管哮喘的发生呈负相关。本项目的目的是在动物模型中确定幽门螺杆菌感染是否影响支气管哮喘的发生。我们研究了幽门螺杆菌感染对卵白蛋白诱导的沙土鼠哮喘严重程度的影响。在Hp感染和未感染的小鼠中，卵清蛋白引起的哮喘严重程度相似，炎症细胞、细胞因子和组织学改变相似。幽门螺杆菌感染可能与哮喘的发生无关。

项目成果

Association between Left-Handedness and Gastrointestinal Symptoms

左利手与胃肠道症状之间的关联

• DOI: 10.1159/000324680
• 发表时间: 2011
• 期刊: Digestion
• 影响因子: 3.2
• 作者: Y. Fujiwara;Makiko Kubo;Y. Kohata;H. Yamagami;T. Tanigawa;Kenji Watanabe;Toshio Watanabe;K. Tominaga;T. Arakawa
• 通讯作者: T. Arakawa

Toll-like receptor 9 signaling has anti-inflammatory effects on the early phase of Helicobacter pylori-induced gastritis

• DOI: 10.1016/j.bbrc.2012.08.080
• 发表时间: 2012-09-28
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Otani, Koji;Tanigawa, Tetsuya;Arakawa, Tetsuo
• 通讯作者: Arakawa, Tetsuo

酸逆流が関連する好酸球性食道炎の臨床的基礎的研究

嗜酸性粒细胞性食管炎伴胃酸反流的临床基础研究

• 发表时间: 2012
• 作者: 藤原靖弘;須川貴史;荒川哲男
• 通讯作者: 荒川哲男

今日の治療指針急性胃炎・急性胃潰瘍

今日治疗指南 急性胃炎/急性胃溃疡

• 发表时间: 2012
• 作者: 大谷恒史;谷川徹也;ほか;荒川哲男
• 通讯作者: 荒川哲男

Role of small intestinal bacterial overgrowth in severe small intestinal damage in chronic non-steroidal anti-inflammatory drug users

• DOI: 10.3109/00365521.2014.880182
• 发表时间: 2014-03-01
• 期刊: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
• 影响因子: 1.9
• 作者: Muraki, Motoko;Fujiwara, Yasuhiro;Arakawa, Tetsuo
• 通讯作者: Arakawa, Tetsuo