Stimulation of liver regeneration and function by IGF-I

刺激肝细胞的增殖和功能对肝衰竭的治疗是重要的。我们研究了igf - 1对肝细胞的刺激作用。igf - 1激活其在肝细胞上的受体，刺激其增殖、蛋白质生成和葡萄糖代谢。这些作用受肝细胞培养条件的调节。在肝星状细胞中，IGF-I促进了细胞的增殖，而IGF-I通过促进胶原降解而减少了胶原的产生。igf - 1刺激肝细胞增殖和功能。此外，它还可能抑制肝纤维化。igf - 1是治疗包括肝衰竭在内的肝脏疾病的候选药物。

Stimulation of proliferation and function by hepatic cells are important for the treatment of liver failure. We studied the stimulatory effect of IGF-I on hepatic cells.IGF-I activated its receptor on hepatocytes, and stimulated its proliferation as well as protein production and glucose metabolism. These effects were regulated by culture conditions of hepatocytes. In hepatic stellate cells, IGF-I enhanced the proliferation, while collagen production was reduced by IGF-I treatment through the enhancement of collagen degradation.IGF-I stimulates hepatocyte proliferation and function. In addition, it may suppress hepatic fibrosis. IGF-I is a candidate as a drug for the treatment of liver diseases including hepatic failure.