The changes in the collagen fiber orientation by aging: an approach to the mechanism of repture of alveolar wall

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1) It was found that the collagen fiber orientations from the aged human lung sample, as well as those from the young human lung sample, were generally orientated parallel to the longitudinal axis of the spine. However, the degree of fiber orientation (DFO) was smaller in the aged human lung than in the young one. The difference was remarkable in the lower lobe.2) In apex of the lung with emphysematous lesions, DFO was remarkably decreased and the direction was random. The area with small DFO was expanded in the advanced emphysematous lung, whereas there was an area in which the DFO was large and the direction was oblique, not parallel to the axis.