Activation of the prefrontal cortex is associated with exertional dyspnea in COPD

前额皮质的激活与 COPD 患者的劳力性呼吸困难有关

• 批准号: 23591128
• 负责人: HIGASHIMOTO Yuji
• 金额: $ 3.33万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591128/
• 关键词: 閉塞性肺疾患; 脳皮質活動; 運動負荷; 近赤外線分光法; 前頭葉; 慢性閉塞性肺疾患; 呼吸困難; 低酸素血症; 間質性肺炎; 前頭葉皮質; 気管支拡張薬; COPD; 脳活動; 前頭前野領域

Background Exertional dyspnea is the primary symptom that limits exercise for patients with chronic obstructive pulmonary disease (COPD). It is unknown which activated brain area is associated with this symptom in COPD patients.Objectives To investigate the activation of cortical areas in COPD patients associated with dyspnea during exercise. Methods COPD patients and age-matched controls performed mild intensity constant-work rate cycle exercises for 10 minutes while cerebral hemodynamics and oxygenation were measured by near-infrared spectroscopy (NIRS). Results Oxy-Hb concentration was significantly increased in the prefrontal region during exercise in both groups, but not in temporoparietal regions. Dyspnea scores were positively correlated with changes in oxy-Hb concentrations of the prefrontal regions in both groups. Conclusions Exertional dyspnea was related to activation (oxygenation) of the prefrontal cortex in COPD patients and control subjects.

背景 劳力性呼吸困难是限制慢性阻塞性肺疾病（COPD）患者运动的主要症状。目前尚不清楚慢性阻塞性肺病患者中哪个大脑区域的激活与该症状相关。目的探讨与运动时呼吸困难相关的慢性阻塞性肺病患者的皮质区域的激活。方法 COPD 患者和年龄匹配的对照者进行 10 分钟的轻度恒定工作率循环运动，同时通过近红外光谱 (NIRS) 测量脑血流动力学和氧合。结果 两组运动期间前额叶区域的氧合血红蛋白浓度均显着增加，但颞顶区域没有显着增加。两组中呼吸困难评分均与前额叶区域氧合血红蛋白浓度的变化呈正相关。结论 COPD 患者和对照受试者的劳力性呼吸困难与前额皮质的激活（氧合）有关。

项目成果

Localization Of Brain Activation Associated With Dyspnea During Exercise With Respiratory Resistance : A Study Using BOLD fMRI, [Publication Page : A4907]

呼吸阻力运动期间与呼吸困难相关的大脑激活的定位：使用 BOLD fMRI 的研究，[出版页：A4907]

• 发表时间: 2013
• 作者: N. Honda;Y. Higashimoto;R. Okada;M. Onoda;K. Maeda;M. Shiraishi;R. Sugiya;S. Okajima;T. Yamagata;K. Terada;Y. Tohda;K. Fukuda
• 通讯作者: K. Fukuda

Localization Of Brain Activation Associated With Dyspnea During Exercise With Respiratory Resistance: A Study Using BOLD fMRI,

呼吸阻力运动期间与呼吸困难相关的大脑激活的定位：一项使用 BOLD fMRI 的研究，

• 发表时间: 2013
• 作者: N Honda;Y Higashimoto;R Okada;M Onoda;K Maeda;M Shiraishi;R Sugiya;S Okajima;T Yamagata;K Terada;Y Tohda;K Fukuda
• 通讯作者: K Fukuda

【copd-その病態と最新治療】ステロイド薬の使い方(吸入・経口)

[慢性阻塞性肺病-其病理生理学和最新治疗方法]如何使用类固醇药物（吸入/口服）

• 发表时间: 2013
• 期刊: カレントテラピー
• 作者: Honda N.;Higashimoto Y.;Fukuda K;(他4名);東本有司,東田有智
• 通讯作者: 東本有司,東田有智

Prefrontal Cortex Activation Is Associated With Dyspnea During Methacholine Bronchial Provocation Tests, [Publication Page : A4105]

乙酰甲胆碱支气管激发试验期间前额皮质激活与呼吸困难相关，[出版页：A4105]

• 发表时间: 2012
• 作者: Y. Higashimoto;N. Okimoto;N. Honda;T. Yamagata;R. Yamazaki;Y. Fukai;S. Innbe;H. Miyajima;H. Santoh;A. Sano;Y. Makino;R. Satoh;O. Nishiyama;H. Sano;T. Iwanaga;H. Nakajima;H. Kume;Y
• 通讯作者: Y

Effect Of Protcaterol "Assist Use" On Quality Of Life And Exercise Capacity In Patients With Chronic Obstructive Pulmonary Disease.

丙卡特罗“辅助使用”对慢性阻塞性肺疾病患者生活质量和运动能力的影响。

• 发表时间: 2012
• 作者: 49.Higashimoto Y;Miyajima H;Ichihashi H;Sano A;Satoh R,Nishiyama O;Sano H;Yamagata T;Iwanaga T;Nakajima H;Tomita K;Kume H;Tohda
• 通讯作者: Tohda