The role of proteoglycans in the modulation of EGFR family and it's ligand in lung fibrosis

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Idiopathic Pulmonary Fibrosis is a progressive disease with poor clinical outcome. And yet treatment strategy has not been well-established. In this study we examined the expression of Epidermal Growth Factor Receptors (EGFR) and it`s ligands in isolated lungs from mouse model of bleomycin-induced pulmonary fibrosis. We compared C56BL6 and Balb/c, a strain known to show stronger fibrotic change and mild fibrotic change with bleomycin, respectively. Proteoglycan expression was concomitantly evaluated with intention to explore the association with EGFR and EGFR ligands. Lungs from C56BL6 mice appeared to have apparent fibrotic changes and higher collagen content compared to Balb/c mice. Expression of amphiregulin, epiregulin, versican and decorin seemed to be lower in C56BL6 compared Balb/c mice, whilst EGFR seemed to be highly expressed in C56BL6. These findings provide bases for further investigation.