The new therapeutic strategy for Chronic Kidney Disease involving CD147/Basigin

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CD147/Basigin, a glycosylated transmembrane protein, plays important roles of cell survival, invasion and metastasis. With regard to diabetes and autoimmune diseases, however, the molecular mechanisminvolving CD147 remains unknown. As CD147 identifies activated regulatory T cell (Treg), the attention has become extended to the autoimmune diseases. Interleukin (IL)-17 producing T cell and Treg also serve important roles in the pathogenesis of SLE. In the present study, lack of CD147 promotes Th17 differentiation through the STAT3 activation, eventually leading to the development of lupus nephritis. On the other hand, CD147 play deleterious effects in renal inflammation caused by ischemia and renal fibrosis through the enhanced infiltration of inflammatory cells. Diabetes is also influenced by CD147 in renal inflammation. Our results may shed light on the mechanisms underlying the pathogenesis of diabetes nephropathy and lupus nephritis.