Role of ADMA in acute kidney injury

ADMA 在急性肾损伤中的作用

• 批准号: 23591210
• 负责人: SEIJI Ueda
• 金额: $ 3.33万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591210/
• 关键词: 急性腎障害; 内皮障害; ADMA; 造影剤腎症; 虚血再還流

Injury to the renal vasculature plays important roles in the pathogenesis of acute kidney injury (AKI). Asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, could enhance kidney injury during AKI by causing vascular damage. (Basic research) We investigated the roles of ADMA in AKI using ischemia/reperfusion (I/R)-induced renal injury model mice. I/R injury-induced oxidative stress may reduce DDAH, a degradading enzyme for ADMA, expression and cause ADMA accumulation, which may contribute to capillary loss and tubular necrosis in the kidney. (Clinical research) We next investigated whether ADMA could be a predictor for AKI in 55 patients undergoing elective coronary angiography (CAG). Although no cases of obvious AKI assessed by changes in creatinine levels were identified, administration of contrast medium caused significant increases in plasma ADMA levels. Further, eleveted ADMA was tended to correlated to annual eGFR loss in these subjects.

肾血管损伤在急性肾损伤（阿基）的发病机制中起着重要作用。内源性NO合酶抑制剂不对称二甲基精氨酸（ADMA）可通过引起血管损伤而加重阿基时的肾损伤。（基础研究）我们使用缺血/再灌注（I/R）诱导的肾损伤模型小鼠研究ADMA在阿基中的作用。I/R损伤诱导的氧化应激可降低DDAH（ADMA降解酶）的表达，并导致ADMA蓄积，这可能导致肾脏毛细血管损失和肾小管坏死。（临床研究）我们接下来研究了ADMA是否可以作为55例接受择期冠状动脉造影术（CAG）的患者阿基的预测因子。尽管未发现通过肌酐水平变化评估的明显阿基病例，但造影剂给药导致血浆ADMA水平显著升高。此外，ADMA升高往往与这些受试者的年度eGFR损失相关。

项目成果

心腎連関におけるジメチルアルギニンの役割

二甲基精氨酸在心肾联系中的作用

• 发表时间: 2011
• 作者: 上田誠二;奥田誠也
• 通讯作者: 奥田誠也

Role of Asymmetric Dimethylarginine in Cardiorenal Syndrome

• DOI: 10.2174/13816128113199990480
• 发表时间: 2014-04-01
• 期刊: CURRENT PHARMACEUTICAL DESIGN
• 影响因子: 3.1
• 作者: Ueda, Seiji;Yamagishi, Sho-ichi;Okuda, Seiya
• 通讯作者: Okuda, Seiya

Tissue level of advanced glycation end products is an independent determinant of high-sensitivity C-reactive protein levels in haemodialysis patients

• DOI: 10.1111/j.1440-1797.2010.01419.x
• 发表时间: 2011-03-01
• 期刊: NEPHROLOGY
• 影响因子: 2.5
• 作者: Nagano, Makio;Fukami, Kei;Okuda, Seiya
• 通讯作者: Okuda, Seiya

Asymmetric dimethylarginine accumulates in the kidney during ischemia/reperfusion injury.

在缺血/再灌注损伤期间，非对称二甲基精氨酸在肾脏中积聚。

• DOI: 10.1038/ki.2013.398
• 发表时间: 2014-03
• 期刊: Kidney international
• 影响因子: 19.6

Association of ADMA with severity of kidney injury and decline in kidney function in IgA nephropathy

ADMA 与 IgA 肾病肾损伤严重程度和肾功能下降的关系

• 发表时间: 2011
• 期刊: Am J Nephrol
• 影响因子: 4.2
• 作者: Fujimi-Hayashida A;Ueda S;Yamagishi S;Kaida Y;Ando R;Nakayama Y;Fukami K;Okuda S
• 通讯作者: Okuda S