Study for plastic change in human cerebellar neurons

小脑神经可塑性在感觉-运动适应任务中具有重要作用。 为了检测人类小脑的可塑性，我们建立了一个临床上有用的棱镜适应任务，使用触摸屏显示器。 我们通过在健康志愿者中进行这项检查，为几个适应参数提供了规范性数据。 首先，我们将这种方法应用于单纯小脑共济失调患者，并显示适应异常，这证实了我们的方法可以检测人类小脑功能障碍。 适应障碍的程度与临床小脑症状的严重程度无关，这表明我们的方法可能检测小脑功能障碍的另一个方面。此外，为了改变小脑神经可塑性，我们在小脑上施加重复经颅磁刺激（rTMS）。 一些小脑适应参数往往会受到反复小脑刺激。

The cerebellar neuro-plasticity has an important role in sensori-motor adaptation tasks. To detect the cerebellar plasticity in humans, we established a clinically useful prism adaptation task using a touch panel monitor. We made normative data for several adaptation parameters by performing this examination in healthy volunteers. First, we applied this method to patients with pure cerebellar ataxia and showed adaptation abnormality, which confirmed that our method should detect cerebellar dysfunction in humans. The degree of the adaptation impairment did not correlated with the severity of clinical cerebellar symptoms, which suggests that our method may detect another aspect of cerebellar dysfunction.Moreover, to modify the cerebellar neural plasticity, we apply repetitive transcranial magnetic stimulation (rTMS) over the cerebellum. Some cerebellar adaptation parameters tended to be affected by repetitive cerebellar stimulation.