Study of the new insulin action in the peripheral tissues

外周组织中胰岛素新作用的研究

• 批准号: 23591313
• 负责人: YOSHIZAWA TATSUYA
• 金额: $ 3.33万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591313/
• 关键词: インスリン; 糖代謝; シグナル伝達; 糖尿病; 腸管

Gut is the tissue that is important to glucose metabolism, but it is not clear about the insulin action to gut. Therefore applicants generated the gut-specific insulin acceptor knockout (IR gutKO) mice and analyzed influence on glucose metabolism.Because IR gutKO mice showed impaired glucose tolerance in the glucose tolerance test, it was revealed that the insulin action to gut played an important role in glucose metabolism. In addition, expressions of many genes concerned with immunoreaction were changed in the duodenum of the IR gutKO mice by the result of the DNA micro array analysis. These results suggest that an enteric insulin signal modulate immune system and change intestinal flora, thereby controlling glucose metabolism.

肠道是对葡萄糖代谢很重要的组织，但尚不清楚胰岛素对肠道的作用。因此，申请人产生了肠道特异性的胰岛素受体敲除（IR Gutko）小鼠并分析了对葡萄糖代谢的影响。因为IR Gutko小鼠在葡萄糖耐受性测试中表现出葡萄糖耐受性受损，因此，胰岛素作用在胰岛素作用中起着重要的作用，在葡萄糖代谢中起重要作用。此外，通过DNA微阵列分析的结果，在IR Gutko小鼠的十二指肠中改变了许多与免疫反应有关的基因的表达。这些结果表明，肠胰岛素信号调节免疫系统并改变肠道菌群，从而控制葡萄糖代谢。