Pathogenesis of hematological malignancies caused by viral infection

一些病毒感染与肿瘤的发生密切相关。2008年，默克尔细胞多瘤病毒(MCPyV)被报道为首例肿瘤多瘤病毒。西方世界已经讨论了MCPyV与慢性淋巴细胞白血病(CLL)的关系，而东方国家CLL病例中MCPyV的流行率尚未调查。在这项研究中，我们确定了MCPyV在日本CLL病例中的患病率和DNA载量。我们发现MCPyV存在于日本CLL的一部分病例中，但MCPyV在日本CLL中的直接致病作用尚不清楚。由于MCPyV也可以感染单核细胞，我们调查了MCPyV在单核细胞系疾病中的患病率。在我们的任何单核细胞白血病样本中都没有检测到MCPyV DNA，这表明MCPyV不太可能在这些患者的单核细胞白血病中起致病作用。

Some virus infections are closely associated with oncogenesis. In 2008, Merkel cell polyomavirus (MCPyV) was reported as the first tumor polyomavirus. The association of MCPyV with chronic lymphocytic leukemia (CLL) has been discussed in the Western world, whereas the prevalence of the virus in CLL cases in Eastern countries has not been investigated. In this study, we determined the prevalence and DNA loads of MCPyV in Japanese CLL cases. We found that MCPyV is present in a subset of Japanese CLL cases, but it is unclear that MCPyV have a direct causal role in Japanese CLL.Since MCPyV can also infect monocytic cells, we investigated the prevalence of MCPyV in disorders of monocytic lineage. MCPyV DNA was not detected in any of our leukemia samples with the monocytic lineage, suggesting that MCPyV is unlikely to have played a pathogenetic role in the monocytic leukemias of these patients.