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Inleetin and pathogenetic role of lymphotropic viruses in hematological malignancies.

嗜淋巴病毒在血液恶性肿瘤中的摄入和致病作用。

基本信息

批准号：
14570986
负责人：
DAIBATA Masanori
金额：
$ 1.98万
依托单位：
Kochi University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570986/
关键词：
Hematological malignancies Epstein-Barr virus human herpesvirus 6 human herpesvirus 8 virus-associated diseases 悪性リンパ腫 Simian virus 40 造血器腫瘍ヒトヘルペスウイルス6 膿胸関連リンパ腫染色体

项目摘要

1.Epstein-Barr virus(EBV) is associated with several lymphoproliferative diseases. Pyothorax-associated lymphoma(PAL) is closely associated with EBV, but how this virus contributes to the development of the lymphoma is known. PAL would provide an excellent model for investigation of virus-associated lymphomagenesis, and establishment of PAL-derived cell lines is desirable. In this study, we have successfully established a novel PAL cell line. The cell line unexpectedly possessed integrated EBV at a specific site. The viral integration event is suggested to enhance a chromosomal instability at the insertion site. The cell line represents the first example of EBV integration in PAL and could enable the study of the role of integrated viral infection in lymphomagenesis.2.EBV and other diseases : (1)It is known that monoclonal EBV infection is observed in 10-15% of gastiric carcinoma. We described for the first time a case of concomitant gastric lymphoma and adult T-cell leukemia/lymphoma in which EBV infected cells were detected. (2)We also proposed that reactivated EBV infection is associated with a subset of pure red cell aplasia.3 Human herpesvirus 6 (HHV-6) and diseases : The etiology and adult onset Still's disease is known. We suggested that reactivated HHV-6 infection could be a causative factor of adult onset Still's disease.4.HHV-8 and diseases : The causative relation between HHV-8 and primary pulmonary hypertension (PPH) has been suggested in USA patients. However, our study showed no association of HHV-8 with PPH in Japanese patients.5 Other virus : Two USA groups reported that simian virus 40 (SV40) was detected in about 40% of lymphoma. In this study, we looked for SV40 in samples from Japanese patients with lymphoproliferative disorders. The virus was detected in only 3 (1.7%) of 178 samples, suggesting that SV40 is unlikely to play a pathogenetic role in Japanese patients.

1.EB病毒(EBV)与多种淋巴组织增生性疾病有关。脓胸相关淋巴瘤 (PAL) 与 EBV 密切相关，但这种病毒如何促进淋巴瘤的发展是已知的。 PAL 将为研究病毒相关淋巴瘤发生提供一个极好的模型，并且建立 PAL 衍生细胞系是可取的。在这项研究中，我们成功建立了一种新型的 PAL 细胞系。该细胞系出乎意料地在特定位点整合了 EBV。建议病毒整合事件增强插入位点的染色体不稳定性。该细胞系代表了EBV整合到PAL中的第一个例子，可以使研究整合病毒感染在淋巴瘤发生中的作用成为可能。2.EBV和其他疾病：(1)已知在10-15%的胃癌中观察到单克隆EBV感染。我们首次描述了一个伴有胃淋巴瘤和成人 T 细胞白血病/淋巴瘤的病例，其中检测到 EBV 感染细胞。 (2)我们还提出，重新激活的 EBV 感染与纯红细胞再生障碍亚型有关。3 人类疱疹病毒 6 (HHV-6) 和疾病：病因和成人发病斯蒂尔病是已知的。我们认为，重新激活的HHV-6感染可能是成人斯蒂尔病发病的致病因素。4.HHV-8和疾病：在美国患者中已提出HHV-8与原发性肺动脉高压(PPH)之间的因果关系。然而，我们的研究表明，HHV-8 与日本患者的 PPH 没有关联。5 其他病毒：美国的两个研究小组报告称，在约 40% 的淋巴瘤中检测到猿猴病毒 40 (SV40)。在这项研究中，我们在日本淋巴组织增生性疾病患者的样本中寻找 SV40。 178 个样本中仅 3 个（1.7%）检测到该病毒，这表明 SV40 不太可能在日本患者中发挥致病作用。