Identification of a novel methylated gene as a prognostic factor in hematological malignancies and its clinical application.

一种新型甲基化基因作为血液恶性肿瘤预后因素的鉴定及其临床应用。

• 批准号: 20591133
• 负责人: DAIBATA Masanori
• 金额: $ 3万
• 依托单位: Kochi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591133/
• 关键词: 血液腫瘍学; 造血器腫瘍; メチル化遺伝子; 癌抑制遺伝子; 造血・器腫瘍; 白血病; 癌遺伝子; ウイルス

Bone morphogenetic proteins (BMP) are multifunctional regulators of cell proliferation and apoptosis in various types of malignant cells. In this study, we investigated BMP-6 promoter methylation in patients with various types of leukemias. The BMP-6 methylation was found preferentially in adult T-cell leukemia (ATL) compared with other types of leukemias. Among subtypes of ATL, the BMP-6 gene was more frequently methylated in aggressive ATL forms of acute and lymphoma types than less malignant chronic ATL and smoldering ATL. Serial analysis demonstrated an increasing methylation of CpG sites in the BMP-6 promoter and the resultant suppression of BMP-6 expression as ATL progressed. These findings suggested that BMP-6 promoter methylation is likely to be a common epigenetic event at later stages of ATL and that the methylation profiles may be useful for the staging of ATL as well as for evaluation of the individual risk of developing the disease.

骨形态发生蛋白（BMP）是多种恶性细胞增殖和凋亡的多功能调节剂。在这项研究中，我们研究了不同类型白血病患者的BMP-6启动子甲基化。与其他类型的白血病相比，BMP-6甲基化倾向于在成人t细胞白血病（ATL）中发现。在ATL亚型中，BMP-6基因在急性和淋巴瘤型侵袭性ATL中甲基化的频率高于恶性程度较低的慢性ATL和阴燃型ATL。序列分析表明，随着ATL的进展，BMP-6启动子中CpG位点的甲基化增加，从而抑制BMP-6的表达。这些发现表明，BMP-6启动子甲基化可能是ATL晚期常见的表观遗传事件，甲基化谱可能有助于ATL的分期以及评估个体患病风险。

项目成果

Isolation and characterization of a novel Staphylococcus aureus bacteriophage, ϕMR25, and its therapeutic potential

• DOI: 10.1007/s00705-010-0623-2
• 发表时间: 2010-03
• 期刊: Archives of Virology
• 影响因子: 2.7
• 作者: Hiroshi Hoshiba;Jumpei Uchiyama;Shin-ichiro Kato;Takako Ujihara;Asako Muraoka;M. Daibata;H. Wakiguchi;S. Matsuzaki

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Cell origin of pyothorax-associated lymphoma : a lymphoma strongly associated with Epstein-Barr virus infection.

脓胸相关淋巴瘤的细胞起源：与 Epstein-Barr 病毒感染密切相关的淋巴瘤。

• 发表时间: 2008
• 期刊: Leukemia. 22
• 作者: Takakuwa T;Tresnasari K;Rahadiani N;Miwa H;Daibata M;Aozasa K.
• 通讯作者: Aozasa K.

Multiple oncogenic viruses identified in ocular surface squamous neoplasis in HIV patients.

在艾滋病毒患者的眼表鳞状肿瘤中发现了多种致癌病毒。

• 发表时间: 2010
• 作者: 村上雅尚、大畑雅典;他
• 通讯作者: 他

Testican 3 expression in adult T-cell leukemia

• DOI: 10.1016/j.leukres.2008.11.006
• 发表时间: 2009-07-01
• 期刊: LEUKEMIA RESEARCH
• 影响因子: 2.7
• 作者: Kamioka, Mikio;Imamura, Jun;Sugiura, Tetsuro
• 通讯作者: Sugiura, Tetsuro