HTLV-1-specific T cell suppression in infected individuals

研究认为，CD8+ T细胞对人T细胞白血病病毒1型（HTLV-1）特异性弱反应可能是成人T细胞白血病（ATL）发生的危险因素之一。在这项研究中，我们发现htlv -1特异性CD8+ T细胞反应低，不仅在大多数ATL患者中可以观察到，而且在少数无症状携带者中也可以观察到。我们还发现，这种低CD8+ T细胞反应可能主要归因于htlv -1特异性CD8+ T细胞本身的功能损伤，部分归因于抗原呈递细胞功能降低以及调节性T细胞和感染细胞的免疫抑制。

It is believed that a weak CD8+ T cell response specific for human T-cell leukemia virus type 1 (HTLV-1) may be one of risk factors for the development of adult T-cell leukemia (ATL). In this study, we showed that a low HTLV-1-specific CD8+ T cell response could be observed not only in most ATL patients but also in a small population of asymptomatic carriers. We also found that this low CD8+ T cell response might be attributed mainly to functional impairment of HTLV-1-specific CD8+ T cells themselves and in part to a reduced function of antigen-presenting cells and an immune suppression by regulatory T cells and infected cells.