Reprograming of rheumatoid synovial cell function by miRNA

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We identified miRNAs, which are induced in fibroblastic synovial cell from a patients with rheumatoid arthritis by treatment with TGFbeta1, a cytokine produced from immune cells. One of the miRNAs targets a transcript of secrete protein, which can be secreted form fibroblastic synovial cell. This implies that a miRNA induced by TGFbeta1 can reduce the secreted protein expression in rheumatoid arthritis. Since the secreted protein is involved in osteoblastgenic process, the miRNA is thought to contribute to osteoblast function in the disease. Namely, a method that regulate this miRNA may leads to enhancement of the bone regeneration process in destructed articular bone in rheumatoid arthritis.