Regeneration of joint structure by adipogenesis induction of fibroblatst synovial cell in rheumatoid arthritis.

点击翻译按钮获取中文摘要

Adipogenesis is clearly inhibited by various inflammatory cytokines in both MSC and FLS. The production of IL-6 is inhibited after adipogenesis in both MSC and FLS. Adipogenesis of MSC disrupt the actin structure, which leads to the less migration ability of the cell. Our results indicate that undifferentiated and proliferating MSC in "bone edema", a recently recognized as inflammatory bone marrow lesion in early stage of rheumatoid arthritis, contribute to the progression of the disease, therefore, the adipogenic induction of MSC and FLS can regenerate a favorable joint environment for maintaining auricular structure.