Structural and functional analysis of small non-coding RNAs using computational simulations

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Recent studies have revealed that some small RNA molecules play important roles such as repression of gene translation in many kinds of living cells. To clarify the mechanism of these small functional RNAs, the tertiary structures of those RNAs are required. In this study we developed a new method of tertiary structure prediction of RNA based on the fragment assembly method. We achieved fast and high-precision prediction by improving fragment libraries and potential energy functions.