Analysis of the pathogenic mechanisms of subacute sclerosing panencephalitis by use of recombinant measles viruses, and its therapeutic application

重组麻疹病毒分析亚急性硬化性全脑炎的致病机制及其治疗应用

• 批准号: 23591510
• 负责人: AYATA Minoru
• 金额: $ 3.24万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-28 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591510/
• 关键词: 亜急性硬化性全脳炎; 麻疹ウイルス; 干渉現象

项目成果

Remarkable similarity in genome nucleotide sequences between the Schwarz FF-8 and AIK-C measles virus vaccine strains and apparent nucleotide differences in the phosphoprotein gene.

Schwarz FF-8 和 AIK-C 麻疹病毒疫苗株之间的基因组核苷酸序列具有显着的相似性，并且磷蛋白基因中存在明显的核苷酸差异。

• DOI: 10.1111/j.1348-0421.2011.00339.x
• 发表时间: 2011
• 期刊: Microbiology and Immunology
• 影响因子: 2.6
• 作者: Ito C;Ohgimoto S;Kato S;Sharma LB;Ayata M;Komase K;Takeuchi K;Ihara T;Ogura H.
• 通讯作者: Ogura H.

Determinants of neurovirulence of the Osaka-1 strain of measles virus derived from a case of subacute sclerosing panencephalitis.

源自亚急性硬化性全脑炎病例的麻疹病毒 Osaka-1 株神经毒力的决定因素。

• 发表时间: 2011
• 作者: M. Ayata;S. Ohgimoto;M. Kuwamura;M. Tanaka;K. Takeuchi;M. Takeda;H. Ogura
• 通讯作者: H. Ogura

Biased hypermutation occurred frequently in a gene inserted into the IC323 recombinant measles virus during its persistence in the brains of nude mice

IC323重组麻疹病毒在裸鼠大脑中持续存在期间，插入IC323重组麻疹病毒的基因经常发生偏向超突变

• DOI: 10.1016/j.virol.2014.05.035
• 发表时间: 2014
• 期刊: Virology
• 影响因子: 3.7
• 作者: Otani S;Ayata M;Takeuchi K;Takeda M;Shintaku H;Ogura H
• 通讯作者: Ogura H

Amino acid substitutions in the heptad repeat A and C regions of the F protein responsible for neurovirulence of measles virus Osaka-1 strain from a patient with subacute sclerosing panencephalitis

• DOI: 10.1016/j.virol.2015.10.004
• 发表时间: 2016-01-01
• 期刊: VIROLOGY
• 影响因子: 3.7
• 作者: Ayata, Minoru;Tanaka, Miyuu;Ogura, Hisashi
• 通讯作者: Ogura, Hisashi