Abnormalities of Peripheral-Brain Axis in Onset of Developmental Origins of Health and Disease (DoHAD) and Prevention by Postnatal Nutoritional Support

本试验研究了断奶和断奶对断奶前期仔猪Nesfatin和GALP基因表达的影响。断乳后，Nesfatin和GALP基因的表达显著增加。再投喂导致GALP基因表达显著降低。提示Nesfatin和GALP可能在断奶前控制饮水和渗透压调节中起作用。我们研究了BDNF和25(OH)VitD水平与肥胖相关代谢并发症的关系。病态肥胖儿童血浆脑源性神经营养因子水平降低与出生体重有关。肥胖儿童青少年血浆25(OH)VitD水平降低与甲状旁腺激素、体重指数、腰围、尿酸有关。我们的结果提示BDNF和维生素D可能在儿童和青少年肥胖和蛋氨酸代谢综合征的发生和病理生理过程中发挥重要作用。

We examined the effect of the milk deprivation and refeeding on the Nesfatin and GALP genes expression during pre-weaning period. After milk deprivation, the Nesfatin and GALP genes expression was significantly increased. Refeeding induced significant decrease of the GALP gene expression. It is suggested that Nesfatin and GALP might have roles in the control of water drinking and osmolality regulation in the preweaning period.We investigated the relationship between plasma levels of BDNF and 25(OH) vit D, and obesity-related metabolic complication. The plasma BDNF levels, which is decreased in the morbidly obese children, are associated with birth weight. The plasma levels of 25(OH) vit D, which is decreased in the obese children and adolescents with MetS, are associated with PTH,BMI, waist circumference and UA. Our results suggest that BDNF and vitamin D may play important roles in the development and pathophysiology of obesity and MetS in childhood and adolescents.