Postnatal development of the brain- adipose axis and its abnormality : as the background of the metabolic syndrome

脑-脂肪轴的出生后发育及其异常：代谢综合征的背景

• 批准号: 20591236
• 负责人: YAMAMOTO Yukiyo
• 金额: $ 2.91万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591236/
• 关键词: Nesfatin-1; 室傍核; 弓状核; 摂食調節; 生後発達; 脳脂肪細胞系; 視床下部; 視索上核; Galanin-like peptide; Neuromedin U; 下垂体後葉; 下垂体前葉; 浸透圧調節

To begin to understand the physiological role of Nesfatin-1 during postnatal development, we examined the developmental changes of the Nesfatin-1 gene expression in the PVN, SON and ARC during postnatal day 1 to day 60, using in situ hybridization histochemistry. Development of Nesfatin-1, which showed different patterns each hypothalamic nucleus during postnatal development, may be associated with its region-specific roles during postnatal development.Next, we examined the effect of the maternal deprivation for twenty-four hours on the gene expression of the Nesfatin-1 during pre-weaning period. After 24 h milk deprivation, the Nesfatin-1 gene expression was significantly increased at postnatal day 15. Significant increase in the expression of the Nesfatin-1 gene after milk deprivation suggested that osmolality change induced by milk deprivation might be a stimulant to induce the expression of the Nesfatin-1 gene in the preweaning period. Development of Nesfatin-1 may be associated with its critical role in the maturation of neurosecretory function in the hypothalamus-pituitary axis.

为了开始了解NESFATIN-1在产后发育过程中的生理作用，我们检查了第1天至第60天，使用原位杂交组织化学，在第1天至第60天，NESFATIN-1基因表达在PVN，SON和ARC中的发育变化。 NESFATIN-1的发育显示出产后发育过程中每个下丘脑核的不同模式，可能与其在产后发育过程中其区域特异性作用有关。我们检查了母体剥夺对二十四小时的影响对24个小时的影响对固定期nesfatin-1的基因表达的影响。 24小时牛奶剥夺后，在产后第15天，NESFATIN-1基因表达显着增加。牛奶剥夺后Nesfatin-1基因的表达显着增加表明，牛奶剥夺引起的渗透压变化可能是刺激性可能是诱导Nesfatin-1基因表达的刺激性。 NESFATIN-1的开发可能与其在下丘脑 - 垂体轴上神经分泌功能成熟中的关键作用有关。

项目成果

Decreased plasma levels of brain-derived neurotrophic factor and its relationship with obesity-related metabolic complication, birth weight and plasma levels of adipocytokines in obese children

肥胖儿童血浆脑源性神经营养因子水平降低及其与肥胖相关代谢并发症、出生体重和血浆脂肪细胞因子水平的关系

• 发表时间: 2010
• 作者: Yamamoto Y;Araki S;Dobashi k;Gotoh M;Kusuhara K
• 通讯作者: Kusuhara K

Developmental changes of neuromedin U and galanin-like peptide gene expressions in the rat pituitary : an analysis by in situ hybridization histochemistry.

大鼠垂体神经调节素 U 和甘丙肽样肽基因表达的发育变化：原位杂交组织化学分析。

• 发表时间: 2010
• 作者: Kubo K;Yamamoto Y;Kawagoe R;Gotoh M;So M;Araki S;Kusuhara K.
• 通讯作者: Kusuhara K.

尿糖陽性で発見された幼児糖尿病の一例

尿糖阳性发现婴儿糖尿病一例

• 发表时间: 2009
• 作者: 河田泰定;荒木俊介;久保和泰;川越倫子;山本幸代;土橋一重;楠原浩一
• 通讯作者: 楠原浩一

長期臥床重症心身障害児における骨代謝マーカーおよび骨塩量の検討

长期卧床严重身心障碍儿童骨代谢标志物及骨矿物质含量检查

• 发表时间: 2009
• 作者: 石井雅宏;山本幸代;斉藤玲子;千手絢子;荒木俊介;久保和泰;川越倫子;河田泰定;下野昌幸;土橋一重
• 通讯作者: 土橋一重

Plasma visfatin concentration as a surrogate marker for visceral fat accumulation in obese children

• DOI: 10.1038/oby.2007.54
• 发表时间: 2008-02-01
• 期刊: OBESITY
• 影响因子: 6.9
• 作者: Araki, Shunsuke;Dobashi, Kazushige;Shirahata, Akira
• 通讯作者: Shirahata, Akira