The role of M1, M2 macrophage and regenerative factors in renal injury and recovery process

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To efficacy the role of Macrophage subclasses in renal injury and glomerulonephritis(GN), we investigate the relationship between M1,M2 macrophage, myeloid-related protein(MRP) 8/14 complex and the laboratory and pathological findings in HUS mice model and IgA nephropathy(IgAN) and Henoch-Schoenlein purpura nephritis(HSPN).The scores of renal M2 macrophage expression in the recovery phase of HUS mice model were higher than those in control mice. MRP 8/14 levels, and glomerular and interstitial MRP8+CD68+ scores at the second biopsy were all higher in unfavorable IgAN than in favorable IgAN. Pathological findings revealed that the proportions of patients with ISKDC more grades III in HSPN with high MRP8/14 values were higher than those in HSPN with low MRP8/14 values. Our findings suggest that M2 macrophage plays important role in the recovery phase of renal injury, and serum MRP8/14 complex levels may be associated with the severity of renal injury.