Prediction of PSA bounce after I-125 prostate brachytherapy

I-125 前列腺近距离放射治疗后 PSA 反弹的预测

• 批准号: 23591848
• 负责人: SUGAWARA AKITOMO
• 金额: $ 2.33万
• 依托单位: Tokai University (2012-2013)Keio University (2011)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591848/
• 关键词: 前立腺癌; 放射線治療

The purpose of the present study was to determine factors that were associated with PSA bounce after I-125 prostate brachytherapy for patients with prostate cancer. After I-125 prostate brachytherapy, PSA was examined periodically. PSA bounce was defined as a rise of at least 0.1 ng/ml greater than a previous PSA level with a subsequent decline equal to, or less than, the initial nadir. As a result, PSA bounce occurred in 32% of patients. The incidence of PSA bounce was significantly higher in younger patients (<=67 years). In multivariate analysis, age was significantly associated with PSA bounce.

本研究的目的是确定前列腺癌患者I-125前列腺近距离放射治疗后与PSA反弹相关的因素。I-125前列腺近距离放射治疗后，定期检查PSA。PSA反弹被定义为比先前PSA水平上升至少0.1 ng/ml，随后下降等于或小于初始最低点。结果，32%的患者出现PSA反弹。PSA反弹的发生率在年轻患者（<=67岁）中明显更高。在多变量分析中，年龄与PSA反弹显著相关。