Analysis of liver function in living donor measured on 99m Tc GSA SPECT/CT 3D fused imaging

99m Tc GSA SPECT/CT 3D 融合成像测量活体供体肝功能分析

• 批准号: 23591869
• 负责人: YAMAMOTO Hidekazu
• 金额: $ 2.08万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591869/
• 关键词: 生体肝移植; 生体ドナー; 肝予備能解析

The purpose of this study is to evaluate hepatic function of living donor by use of 99m Tc-Galactosyl serum albumin (GSA) single-photon emission computed tomography (SPECT)/CT 3D fused imaging.A total of 65 living donors who underwent hepatectomy were enrolled. The liver uptake ratio (LUR) were calculated based on fused imaging preoperatively and postoperatively. LUR was lower in the cases with pathological liver steatosis and fibrosis. LUR wasn't related to aged liver. The changing ratio in remnant liver volumes between one and four weeks were 0.89-2.11 (median; 1.33) and 0.96-2.73 (median; 1.48). The changes of LUR value of remnant liver between one and four weeks after LDLT were 0.92-1.77 (median; 1.32) and 0.83-1.44 (median; 1.02), respectively. Postoperative hyperbillirubinemia were associated with lower remnant liver volume and preoperative LUR. In conclusion, 99mTc-GSA SPECT/CT fused imaging was clinically useful to evaluate postoperative hepatic function of living donor.

本研究旨在应用99mTc-半乳糖基血清白蛋白(GSA)单光子发射计算机断层扫描(SPECT)/CT三维融合显像评价活体供者的肝功能。术前、术后根据融合图像计算肝脏摄取率(LUR)。病理性肝脂肪变性和肝纤维化患者的LUR较低。LUR与肝脏老化无关。1周至4周的残肝体积变化率分别为0.89~2.11(中位数：1.33)和0.96~2.73(中位数：1.48)。术后1~4周残肝LUR值变化分别为0.92~1.77(中位数1.32)和0.83~1.44(中位数1.02)。术后高胆红素血症与残肝体积较小和术前LUR有关。结论：99mTC-GSA SPECT/CT融合显像对评价活体供肝术后肝功能有一定的临床应用价值。