CXCR4-CXCL12 signaling pathway is an important biological mediator in colorectal cancer cells

我们研究了CXCR 4-CXCL 12信号通路在结直肠癌细胞中的作用和机制。CXCR 4-CXCL 12系统在表达CXCR 4的结直肠癌细胞的增殖、侵袭和管形成中起作用。抗癌药物：5 FU通过下调CXCR 4表达抑制大肠癌细胞的增殖和侵袭活性。CXCR 4-CXCL 12信号通路是大肠癌细胞重要的生物学介质，提示其是大肠癌细胞转移活性发挥的重要因素。

We examined the effect and mechanism of CXCR4-CXCL12 signaling pathway in colorectal cancer cells. The CXCR4-CXCL12 system plays a role for proliferation, invasion, and tube formation of CXCR4-expressing colorectal cancer cells. Anticancer drug: 5FU inhibited proliferation and invasion activity of the colorectal cancer cells through down-regulation of CXCR4 expression. The CXCR4-CXCL12 signaling is an important biological mediator of colorectal cancer cells, suggesting that it is an important factor for the function of metastatic activity.