CXCR4-CXCL12 signaling pathway is an important biological mediator in colorectal cancer cells

CXCR4-CXCL12信号通路是结直肠癌细胞中重要的生物介质

• 批准号: 23591957
• 负责人: YAMAGUCHO Akio
• 金额: $ 3.33万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591957/
• 关键词: 大腸癌; ケモカイン; ケモカインレセプター; 浸潤; 転移; CXCR4; CXCL12

We examined the effect and mechanism of CXCR4-CXCL12 signaling pathway in colorectal cancer cells. The CXCR4-CXCL12 system plays a role for proliferation, invasion, and tube formation of CXCR4-expressing colorectal cancer cells. Anticancer drug: 5FU inhibited proliferation and invasion activity of the colorectal cancer cells through down-regulation of CXCR4 expression. The CXCR4-CXCL12 signaling is an important biological mediator of colorectal cancer cells, suggesting that it is an important factor for the function of metastatic activity.

我们研究了CXCR4-CXCL12信号通路在结直肠癌细胞中的作用及其机制。CXCR4-CXCL12系统对表达CXCR4的结直肠癌细胞的增殖、侵袭和管状形成起作用。抗癌药物：5FU通过下调CXCR4的表达抑制结直肠癌细胞的增殖和侵袭活性。CXCR4-CXCL12信号转导通路是结直肠癌细胞重要的生物介体，提示其是影响肿瘤转移活性的重要因素。