Evaluation of the expression of transcription factors in pathogenesis of autoimmune arthritis

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We have examined the role of tanscription factors controlling the differentiation of CD4+ T cells in the development of autoimmune arthritis. In the analyses in mouse model of autoimmune arthritis, we showed that Th-17 specific master transcrption factor RORgt expressing Foxp3+ regulatory T cells might inhibit the development of autoimmune arthritis. In human studies, we observed that RORgt highly expresess in CD4+ T cells isolated from pelipheral blood in patients with rheumatoid arthritis compared with that in healthy controls.Our results suggested the possibility that control of the expression of transcription factors in CD4+ T cells might be a novel tharapeutic strategy in autoimmune arthritis.