Early Diagnosis of metastatic lung cancer by synchrotron radiation angiography

同步辐射血管造影早期诊断转移性肺癌

• 批准号: 23592053
• 负责人: SAKAKIBARA Yuzuru
• 金额: $ 3.24万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592053/
• 关键词: 転移性肺腫瘍; 早期診断; 放射光血管造影; ラット; 造影剤; 放射光; 肺癌; 血管造影; HARP撮像間; HARP受像管; 微小癌; 転移; 新生血管

Detection of lung cancer is usually performed by chest X-ray or chest computed tomography scan. Minimal size of suspected lung tumor by high resolution CT scan is around 2 or 3 mm. One of the main features of tumor vessel is enhanced permeability across the vessel wall. By use of this property applying contrast material, we tried to find out small metastatic lung tumors employing synchrotron radiation angiography, which equipped high spatial resolution, high density resolution and high time resolution. Rat model of lung metastatic tumor was created using C6 cells. As a result, tumors around 500 um in diameter were recognized. The diagnosis was made effectively based on time-density attenuation curve in suspected tumors comparing with other vessels or background of lung field.

肺癌的检测通常通过胸部X射线或胸部计算机断层扫描进行。通过高分辨率CT扫描，疑似肺肿瘤的最小尺寸约为2或3 mm。肿瘤血管的主要特征之一是血管壁的渗透性增强。利用造影剂的这一特性，我们尝试用同步辐射血管造影技术，以高空间分辨率、高密度分辨率和高时间分辨率，发现肺小转移瘤。用C6细胞建立大鼠肺转移瘤模型。结果，识别出直径约500 μ m的肿瘤。根据时间-密度衰减曲线对可疑肿瘤与其他血管或肺野背景进行比较，可有效地作出诊断。