A development of the treatment method without direct bypass for cerebral hypoperfusion

非直接搭桥脑低灌注治疗方法的研制

• 批准号: 23592098
• 负责人: OHMORI Yuki
• 金额: $ 3.24万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592098/
• 关键词: 慢性脳血流低下; G-CSF; 血管新生; 間接血行再建術; G－CSF; バナジン酸

Chronic cerebral hypoperfusion is found in diseases such as major intracranial artery stenosis or occlusion and moyamoya disease. Chronic hypoperfusion conditions often cause cerebral infarction and Cognitive dysfunction. It is expected that the number of patients increases due to the acceleration of aging in the future. Therefore we studied in order to develop a minimally invasive and effective treatment. There were significant angiogenic effect when we performed indirect revascularization and administered G-CSF in chronic cerebral hypoperfusion rat model. Moreover, it was found that the angiogenic effect of superficial temporal artery and the middle meningeal artery was high when we evaluated the chronic cerebral hypoperfusion patients by cerebral angiography after direct and indirect revascularization. Therefore, it was suggested strongly that the method we have performed in animal experiments might be effective in clinically.

慢性脑低灌注可见于主要的颅内动脉狭窄或闭塞和烟雾病。慢性低灌注症常导致脑梗塞和认知功能障碍。预计未来由于老龄化加快，患者数量将会增加。因此，我们研究以开发一种微创、有效的治疗方法。在慢性脑低灌流大鼠模型上，采用间接血管重建术加G-CSF治疗，有明显的血管生成作用。另外，对直接和间接血运重建后的慢性脑低灌注患者进行脑血管造影检查时，发现颞浅动脉和脑膜中动脉的血管生成效果较好。因此，我们在动物实验中所采用的方法可能在临床上是有效的。

项目成果

Granulocyte Colony-Stimulating Factor Enhances the Angiogenetic Effect of Indirect Bypass Surgery for Chronic Cerebral Hypoperfusion in a Rat Model

• DOI: 10.1227/neu.0b013e31820c0289
• 发表时间: 2011-05-01
• 期刊: NEUROSURGERY
• 影响因子: 4.8
• 作者: Ohmori, Yuki;Morioka, Motohiro;Kuratsu, Jun-ichi
• 通讯作者: Kuratsu, Jun-ichi