A new therapeutic strategy using adenovirus vector REIC gene in a new glioblastoma (GBM) mice model

尽管采用了包括肿瘤切除、化疗和放疗在内的积极和多模式治疗，多形性胶质母细胞瘤（GBM）仍然无法治愈。肿瘤干细胞理论假定肿瘤是由具有自我更新能力和产生异质肿瘤细胞的能力的精选细胞群维持的。Saya等人基于胶质母细胞瘤胶质瘤干细胞的存在，建立了新的GBM模型。在其他地方，我们证明Dickkopf家族3 （DKK3）在GBM细胞中下调，其过表达通过caspase依赖性凋亡显著抑制其生长。我们的研究目的是：1)在我们的研究所建立这个模型；2)评估Ad-DKK3在GBM小鼠模型中的作用；3)验证DKK3的作用机制。我们部分验证了DKK3治疗GBM的作用机制，并将论文提交给Cancer Letter。

Glioblastoma multiform (GBM) remains incurable despite the use of aggressive and multimodal therapies involving tumor resection, chemotherapy and radiation therapy. The cancer stem cell theory postulates that tumors are sustained by a select cell population with self-renewal ability and the capacity to give rise to a heterogeneous mass of tumor cells. Based on the existence of glioma stem cells for glioblastoma, Saya et al. established the new GBM model. Elsewhere we demonstrated that Dickkopf family3 (DKK3) was down-regulated in GBM cells and that its over-expression drastically inhibited their growth via caspase-dependent apoptosis. The aim of our study was 1) to establish this model in our institute and 2) to assess the efficacy of Ad-DKK3 in the GBM mice model and 3) to verify the mechanisms underlying the efficacy of DKK3. We partly verified the mechanisms underlying the efficacy by DKK3 in GBM and submitted our paper to Cancer Letter.