Human chorionic gonadotropin mediated intercellular signalling in human endometrial epithelial cells at implantation site

人绒毛膜促性腺激素介导的人子宫内膜上皮细胞植入部位的细胞间信号传导

• 批准号: 23592399
• 负责人: TAMURA Naoaki
• 金额: $ 3.41万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592399/
• 关键词: 着床; ヒト絨毛性ゴナドトロピン; 子宮内膜上皮細胞; トロフィニン; 子宮内膜; トロフォブラスト; hCG; MUC1; 胎盤; 子宮

Under hCG treatment, expression levels of trophinin was enhanced and MUC1 was decreased in Ishikawa cells, one of endometrial epithelial cell lines. These alternations were more remarkable under hCG and IL-1beta treatment. From the Microarray analysis, gene expression levels of ADM and KISS1R were decreased in Ishikawa cells under hCG treatment.Genetic splicing variants of trophinin existed in Ishikawa cells. This fact suggested that trophinin may coordinate its function by dominant negative manner in vivo.

hCG处理后，子宫内膜上皮细胞株之一的石川细胞的trophinin表达增强，MUC 1表达降低。这些变化在hCG和IL-1 β处理下更为显著。基因芯片分析显示，hCG处理后石川细胞ADM和KISS 1 R基因表达水平降低，石川细胞中存在trophinin基因剪接变异体。提示营养素在体内可能以显性负性方式协调其功能。

项目成果

Real time cerebral hemodynamics evalution by Time-Resolved Spectroscopy (TRS-20) during cesarean operation.

剖宫产手术期间通过时间分辨光谱 (TRS-20) 进行实时脑血流动力学评估。

• 发表时间: 2012
• 作者: Yamazaki K;Itoh H;Muramatsu K;Nagahashi K;Nakamura Y;Tamura N;Uchida T;Suzuki K;Kanayama N.
• 通讯作者: Kanayama N.

Infantile growth after indernourishment in utero positively correlates with chronic inflammatory reactions in the white adipose tissues of adult mice, as a risk of developing obesity.

子宫内营养不良后的婴儿生长与成年小鼠白色脂肪组织中的慢性炎症反应呈正相关，这是发生肥胖的风险。

• 发表时间: 2012
• 作者: Itoh H;Kohmura Y;Muramatsu K;Yamazaki K;Nagahashi K;Nakamura Y;Tamura N;Uchida T;Suzuki K;Kanayama N.
• 通讯作者: Kanayama N.

臨床婦人科産科【早産の予防・診断】早産と細菌性腟症

临床妇产科【早产的预防与诊断】早产与细菌性阴道病

• 发表时间: 2011
• 作者: Li D;Takao T;Tsunematsu R;Morokuma S;Fukushima K;Kobayashi H;Saito T;Furue M;Wake N;Asanoma K;田村直顕，伊東宏晃
• 通讯作者: 田村直顕，伊東宏晃

早産 産婦人科学レビュー＜最新主要文献と解説＞

早产妇产科综述<最新主要文献及评论>

• 发表时间: 2011
• 作者: 0Mijiddorj T;Kanasaki H;Purwana IN;Oride A;Sukhbaatar U and Miyazaki K;田村直顕，金山尚裕
• 通讯作者: 田村直顕，金山尚裕

Trophinin in cell adhesion and signal transduction.

• DOI: 10.2741/381
• 发表时间: 2012
• 期刊: Frontiers in bioscience
• 作者: M. Fukuda;K. Sugihara