Detection of mutagenic molecule for cervical cancer

正常的阴道菌群由主要的乳酸杆菌和次要的好氧/厌氧细菌组成，保持阴道清洁。厌氧细菌或阴道弧菌的过度生长导致细菌性阴道病。在厌氧菌或阴道g.g inalis过度生长的情况下，HPV感染存在多种基因型，提示HPV感染与厌氧菌或阴道g.g inalis在癌前状态下存在网络。HPV感染在高级别上皮内病变导致免疫反应增强。这种机制可能对病情发展有一定的负面影响。相反，HPV感染对正常或低级别上皮内病变的免疫逃逸有影响。病毒感染与宿主免疫反应的平衡可能是子宫颈多步骤癌变的关键。

The normal vaginal flora composed of both major lactobacillus and minor aerobic/anaerobic bacteria, keep the vaginal cleanliness. Overgrowth of the anaerobic bacteria or G. Vaginalis causes bacterial vaginosis. The multiple genotypes of HPV infection were observed under the overgrowth of anaerobic bacteria or G. Vaginalis, suggesting HPV infection and anaerobic bacteria or G. Vaginalis have network in premalignant status.HPV infection in the high grade of intraepithelial lesion results in the enhancement of immune response. This mechanism might have some negative effect on the progression. In contrast, HPV infections have an effect on the immune escape in the normal or low grade intraepithelial lesions. The balance of the viral infection and host immune response might be crucial for the multistep carcinogenesis in the cervix.