p16(INK4a) immunohistochemistry is a promising biomarker to predict the outcome of low grade cervical intraepithelial neoplasia: comparison study with HPV genotyping.
p16(INK4a) immunohistochemistry is a promising biomarker to predict the outcome of low grade cervical intraepithelial neoplasia: comparison study with HPV genotyping.
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DOI：
10.3802/jgo.2013.24.3.215
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发表时间：
2013-07
影响因子：
3.9
通讯作者：
Aoki D
中科院分区：
文献类型：
--
作者：
Nishio S;Fujii T;Nishio H;Kameyama K;Saito M;Iwata T;Kubushiro K;Aoki D
在宫颈上皮内瘤变（CIN）中，p16 INK 4a免疫组织化学已被报道是一种有用的诊断生物标志物。然而，关于p16 INK 4a免疫组化与CIN结局之间的相关性的信息有限。在这里，我们报告p16 INK 4a免疫组化作为一个有效的生物标志物，预测CIN的结果。对2000年1月至2009年8月间的CIN患者进行p16 INK 4a免疫组化。我们对这些患者的病历进行回顾性分析，以评估CIN 1-2的结局，并进行统计分析，以确定p16 INK 4a表达与结局之间的相关性。我们还进行了HPV基因分型，并分析了感染的人乳头瘤病毒（HPV）基因型与预后的关系。共检查了244例患者，其中CIN 1型82例，CIN 2型60例，CIN 3型102例。p16 INK 4a过表达率随CIN分级的增高而增高，CIN 1、2、3级分别为20.7%、80.0%、89.2%，CIN 1组与CIN 2-3组比较差异有显著性（P <0.05）。在131例CIN 1-2患者中，显示p16 INK 4a过表达的患者的进展率显著高于未显示p16 INK 4a过表达的患者（p=0.005）;还发现显示p16 INK 4a过表达的患者的消退率显著较低（p=0.003）。高危型HPV阳性率为73.7%。高危HPV阳性组和HPV阴性组之间的进展率和消退率均无显著差异（分别为p=0.401和p=0.381）。p16 INK 4a过表达与CIN 1-2的预后相关，与HPV基因分型相比，p16 INK 4a被认为是预测CIN 1-2预后的一个上级生物标志物。
In cervical intraepithelial neoplasia (CIN), p16INK4a immunohistochemistry has been reported to be a useful diagnostic biomarker. However, limited information is available about the association between the p16INK4a immunohistochemistry and the outcomes of CIN. Here, we report p16INK4a immunohistochemistry as an effective biomarker to predict the outcomes of CIN. p16INK4a immunohistochemistry was performed in patients with CIN from January 2000 to August 2009. Among these patients, we have performed a retrospective analysis of the medical records to evaluate the outcome of CIN 1-2 and performed statistical analysis to determine the correlation between p16INK4a expression and the outcomes. We also performed HPV genotyping and analyzed the relation between the infecting human papillomavirus (HPV) genotype and the outcomes. A total of 244 patients, including 82 with CIN 1, 60 with CIN 2, and 102 with CIN 3, were examined. The rate of p16INK4a overexpression increased with increasing CIN grade, 20.7% for CIN 1, 80.0% for CIN 2, and 89.2% for CIN 3, with significant differences between CIN 1 and CIN 2-3 group. In the 131 CIN 1-2 patients, the progression rate was significantly higher for the patients showing p16INK4a overexpression than for those not showing p16INK4a overexpression (p=0.005); the regression rate was also found to be significantly lower for the patients showing p16INK4a overexpression (p=0.003). High-risk HPV genotypes were detected in 73 patients (73.7%). Both progression and regression rates were not significantly different between the high-risk HPV-positive and HPV-negative groups (p=0.401 and p=0.381, respectively). p16INK4a overexpression was correlated with the outcome of CIN 1-2, and p16INK4a is considered to be a superior biomarker for predicting the outcome of CIN 1-2 compared with HPV genotyping.
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影响因子：
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作者：
Fujii, Takuma;Saito, Miyuki;Aoki, Daisuke
通讯作者：
Aoki, Daisuke
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