Age-related olfactory dysfunction: cellular and molecular analyses

与年龄相关的嗅觉功能障碍：细胞和分子分析

• 批准号: 23592506
• 负责人: KONDO Kenji
• 金额: $ 3.24万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592506/
• 关键词: 鼻科学; 嗅覚障害; 加齢変化; カロリー制限; エストロゲン; 感冒罹患後嗅覚障害; FAT-1マウス; 嗅覚医学; 嗅神経障害; 神経再生; 嗅覚; 嗅神経上皮; 再生

1. Caloric restriction exacerbated the age-related neuroepithelial degeneration in the mouse olfactory mucosa and also worsened the regeneration of the olfactory neuroepithelium after injury. The downregulation of proliferative activity in neuroepithelium by caloric restriction appeared to play an important role in the pathogenesis. 2. The immune model of postviral olfactory disorder (PVOD) was developed in mice using Poly(I:C), a synthetic analog of viral double-stranded RNA. The analyses suggested that the secondary damage caused by the neutrophil-mediated innate immune response plays an important role in the pathogenesis of PVOD. 3. The analyses of estrogen receptor beta (ERbeta) -deficient mice suggested that estrogen plays a role in the homeostasis of the olfactory mucosa through ERbeta. 4. FAT-1 mice demonstrated better neuroepithelical regeneration after injury, suggesting that the tissue fatty acid is associated with the regeneration of the olfactory neuroepithelium.

1.热量限制可加重小鼠嗅粘膜神经上皮的老化性变性，并使损伤后的嗅神经上皮再生恶化。通过热量限制下调神经上皮细胞的增殖活性似乎在发病机制中起重要作用。2.使用Poly（I：C）（病毒双链RNA的合成类似物）在小鼠中建立病毒后嗅觉障碍（PVOD）的免疫模型。提示嗜中性粒细胞介导的天然免疫反应所引起的继发性损伤在PVOD的发病中起重要作用。3.对雌激素受体β（ER β）缺陷小鼠的分析表明，雌激素通过ER β在嗅粘膜的稳态中起作用。4. FAT-1小鼠在损伤后表现出更好的神经上皮再生，表明组织脂肪酸与嗅神经上皮的再生有关。

项目成果

Immune response, neuroepithelial degeneration and regeneration induced by intranasal administrationof Poly(I : C) in the mouse olfactory mucosa

鼻内给予Poly(I:C)诱导小鼠嗅粘膜的免疫反应、神经上皮变性和再生

• 发表时间: 2012
• 作者: Kanaya K;Kondo K;Suzukawa K;Sakamoto T,Yamasoba T
• 通讯作者: Sakamoto T,Yamasoba T

Age-Related Changes of the Regeneration Mode in the Mouse Peripheral Olfactory System Following Olfactotoxic Drug Methimazole-Induced Damage

• DOI: 10.1002/cne.22611
• 发表时间: 2011-08-01
• 期刊: JOURNAL OF COMPARATIVE NEUROLOGY
• 影响因子: 2.5
• 作者: Suzukawa, Keigo;Kondo, Kenji;Yamasoba, Tatsuya
• 通讯作者: Yamasoba, Tatsuya

東京大学医学部耳鼻咽喉科学教室

东京大学医学部耳鼻喉科

加齢に伴う嗅神経上皮の再生能低下の病態生理

与年龄相关的嗅神经上皮再生能力下降的病理生理学

• 发表时间: 2011
• 作者: 近藤健二;鈴川佳吾;山岨達也
• 通讯作者: 山岨達也

Age-related Changes of the Regeneration Mode in the Mouse Peripheral Olfactory System

小鼠外周嗅觉系统再生模式随年龄的变化

• 发表时间: 2011
• 作者: Noda K;Kodama S;Umemoto S;Nomi N;Hirano T;Suzuki M;Kondo K
• 通讯作者: Kondo K