Elucidation and innovative drug development development of the cytokine network in the condition of a patient formation of acidophile-related sinusitis

我们试图确定与嗜酸性鼻窦炎发病相关的外在和内在因素。我们发现，包括金黄色葡萄球菌中的外毒素、真菌抗原、TLR激动剂和蛋白水解酶在内的微生物成分调节着IL-5、IL-13、干扰素-γ、IL-17A、IL-18、IL-33、IL-22和IL-10等细胞因子网络，并参与了嗜酸性鼻窦炎的发病机制，包括鼻息肉的形成、鼻息肉中的嗜酸性粒细胞渗入、鼻窦炎的放射学严重程度和下呼吸道阻塞。

We sought to determine the extrinsic and intrinsic factors involving the pathogenesis of eosinophilic rhinosinusitis. We found that microbial components including exotoxins in Staphylococcus aureus, fungal antigens, TLR agonists and proteases regulates cytokine networks including IL-5, IL-13, IFN-gamma, IL-17A, IL-18, IL-33, IL-22 and IL-10, and involved in the pathogenesis of eosinophilic rhinosinusitis including nasal polyp formation, eosinophil infiltration into nasal polyps, radiological severity of rhinosinusitis, and lower airway obstruction.