Elucidation of the cancer stem cell activation mechanism by EMT in invasion and metastasis of head and neck cancer

阐明EMT在头颈癌侵袭转移中的肿瘤干细胞激活机制

• 批准号: 23592537
• 负责人: OTA Ichiro
• 金额: $ 3.24万
• 依托单位: Nara Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592537/
• 关键词: 頭頸部がん; 癌幹細胞; 浸潤・転移; EMT; 頭頸部外科学

In head and neck cancer cells, we investigated whether Wnt/Snail signaling pathway could induce epithelial-mesenchymal transition, EMT, promote the activation of cancer stem cells, and enhance cancer cel invasion and metastasis. As a result, it was found in the in vivo and in vitro study that Wnt/Snail signaling pathway could induce cancer invasion and metastasis though EMT. In addition, the cancer cells induced EMT by Snail could acquire the cancer stem cell-like properties, such as enhancement of treatment-resistant and expression of cancer stem cell marker. Controlling these signaling pathways involved in EMT will lead to controlling the invasion and metastasis of head and neck cancer.

在头颈部肿瘤细胞中，我们研究了Wnt/Snail信号通路是否能够诱导上皮间质转化（epithelial-mesenchymal transition，EMT），促进肿瘤干细胞的活化，增强肿瘤细胞的侵袭和转移。因此，在体内和体外研究中发现，Wnt/Snail信号通路可以通过EMT诱导肿瘤的侵袭和转移。此外，Snail诱导的EMT可使肿瘤细胞获得肿瘤干细胞样特性，如增强肿瘤干细胞标记物的表达和增强肿瘤的耐药性。控制这些参与EMT的信号通路将导致控制头颈癌的侵袭和转移。

项目成果

Snail1 regulates MMP- dependent invasive activities through cancer cell EMT programs in head and neck cancer cells

Snail1 通过头颈癌细胞中的癌细胞 EMT 程序调节 MMP 依赖性侵袭活动

• 发表时间: 2012
• 作者: Ota I;Masui T;Yane K;Okamoto N;Hosoi H
• 通讯作者: Hosoi H

頭頸部癌における分子標的治療

头颈癌的分子靶向治疗

• 发表时间: 2011
• 作者: Higuchi;Akon;中岡一敏;太田一郎
• 通讯作者: 太田一郎

Low-intensity ultrasound enhances the anticancer activity of cetuximab in human head and neck cancer cells.

• DOI: 10.3892/etm.2012.739
• 发表时间: 2013-01
• 期刊: Experimental and therapeutic medicine
• 影响因子: 2.7
• 作者: Masui T;Ota I;Kanno M;Yane K;Hosoi H
• 通讯作者: Hosoi H

Combination of cetuximab and low-intensity ultrasound causes a synergistic enhancement in cell killing and an additive enhancement in apoptosis induction in human head and neck cancer cells

西妥昔单抗和低强度超声的组合可协同增强细胞杀伤作用，并进一步增强人头颈癌细胞的凋亡诱导作用

• 发表时间: 2011
• 作者: Takashi Masui;他3名
• 通讯作者: 他3名

がん研究UP TO DATE 2013世界の基礎研究の動向

2013 年最新癌症研究 全球基础研究趋势

• 发表时间: 2013
• 作者: 桝井貴史;太田一郎;広中安佐子;武田麻衣子;笠井孝彦;山内晶世;土田澄代;高沢伸;細井裕司;太田一郎
• 通讯作者: 太田一郎