Radioprotective assay on bone metabolism with Japanese Medaka (Oryzias latipes)

点击翻译按钮获取中文摘要

We investigated bone metabolism signaling protein biochemically such as osteoclast-induced cytokine using the pharyngeal bones of medaka (Oryzias) after irradiation. Periostin, which frequency expressed osteoblast, was found in bone invasive tumors and also could significantly affect on bone metabolism. Moreover, periostin was expressed on the calcification and the maturation of osteoblast. However, the effects of periostin on bone metabolism are still not clear about carbon ion irradiation enhanced the expression of periostin on osteoblast cells. The result of this study showed that carbon ion irradiation can increase periostin on osteoblast cell. Furthermore, the irradiated osteoblast cell also express high representation of calcification factor and bone maturation factor. Carbon ion radiotherapy might promote the prevention of bone absorption and the pathological fracture after exposure irradiation.