The elucidation of angiogenic and lymphangiogenic mechanism of the oral cancer by novel MIAgenefamily

我们发现黑色素瘤抑制活性（MIA）是口腔鳞状细胞癌中新的血管和淋巴管生成因子。最近，MIA2和TANGO基因被鉴定为新的MIA基因家族。MIA 2和TANGO在大肠癌、肝癌、恶性黑色素瘤等肿瘤中起抑癌基因的作用，但MIA基因家族在恶性肿瘤中的功能尚不清楚，我们对MIA 2和TANGO在口腔鳞癌中的功能进行了更详细的研究。我们的研究结果表明，MIA2和TANGO在口腔癌中具有致癌功能。

We revealed that melanoma inhibitory activity (MIA) is newly angiogenic and lymphangiogenic factor in oral squamous cell caarcinoma. More recently, MIA2 and TANGO genes were identified as novel MIA gene family. MIA2 and TANGO act as tumor suppressor gene in colorectal cancer, hepatocellular carcinoma, malignant melanoma, and so on. However,functional role of MIA gene family in malignancies are still unknownWe investigated more detailed functions of MIA2 and TANGO in oral squamous cell carcinoma. Our results suggested that MIA2 and TANGO have oncogenic function in oral cancer.