Administrative Supplement: “Mamma Mia”: A multisite randomized controlled trial of an internet-based program for preventing and reducing perinatal depressive symptoms
行政补充:《妈妈咪呀》:预防和减少围产期抑郁症状的基于互联网的计划的多中心随机对照试验
基本信息
- 批准号:10382034
- 负责人:
- 金额:$ 25.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-01 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdministrative SupplementAffectAnxietyBehavioralBirthBlood PressureCOVID-19COVID-19 pandemicCessation of lifeClinicalCommon Data ElementCommunitiesCountryDiscriminationDomestic ViolenceEconomicsEducationEmploymentEnrollmentEthnic OriginFoodFutureGoalsHealthHousingInternetKnowledgeMaternal HealthMaternal MortalityMaternal and Child HealthMeasuresMediator of activation proteinMental HealthMinority GroupsMoodsMorbidity - disease rateOutcomeOutcome StudyParentsParticipantPerinatalPhenX ToolkitPostpartum WomenPregnancyPregnancy ComplicationsPregnant WomenPremature BirthRaceRandomized Controlled TrialsRegistriesResearchRiskRisk FactorsSARS-CoV-2 infectionSiteStressStructural RacismStructureSymptomsTimeTimeLineTraumaUnderrepresented MinorityWomanbasecopingdata harmonizationdepressive symptomsdesignintersectionalityintervention effectmaternal morbiditymental functionmortalitypandemic diseaseperinatal depressive symptomperinatal healthperinatal mental healthpreventprogramsrecruitresilienceresponsesocial culturesocial exclusionsociodemographic factorsstudy populationtreatment as usualunderserved minority
项目摘要
Project Summary - for Administrative Supplement to the Mamma Mia Study (1R01HD100395-01; PI:
Kinser)
This request for an administrative supplement is in response to NOT-OD-21-071. Summary of Parent Study:
The parent study (1R01HD100395-01), or the “Mamma Mia Study”, is a large-scale multi-site randomized
controlled trial (RCT) evaluating the effects of an internet and mobile-based approach (Mamma Mia) for
preventing and intervening with perinatal depressive and related symptoms in n=1950 diverse women across
the country. In particular, the purpose of this longitudinal multisite three-group RCT is to compare the effects,
and explore mediators and moderators of these effects, of three groups: Mamma Mia (self-guided internet/
mobile-based program); Mamma Mia Plus (self-guided internet/mobile-based program PLUS guided clinical
support); and, usual care. The parent study has successfully met study timelines; we have enrolled n=523
participants in Year 1 and anticipate enrolling n=600 participants during the period of the administrative
supplement. Summary of Administrative Supplement: The supplement will explore several questions to
address three goals defined in NOT-OD-21-071, addressing maternal mortality and morbidity in the context of
the COVID-19 pandemic: (1) How does SARS-CoV-2 infection affect mental health and functioning of the
Mamma Mia study population? (2) Does the perceived impact of the COVID-19 pandemic increase risk for
depressive symptoms in pregnant and postpartum women, and does this perceived impact serve as a
moderator of the effects of the intervention over time? (3) What is the impact of structural racism and
discrimination on maternal health outcomes of the study population in the context of COVID-19? Specifically,
how do sociodemographic factors, marginalization and intersectionality (e.g., race/ethnicity, education status,
type of employment), contextualized stress (using measures designed specifically for underrepresented
minority women), and perceived discrimination relate to risk of depressive symptoms in pregnant and
postpartum women, and do these moderate the effects of the intervention over time? How do these factors
relate to birth outcomes, pregnancy complications, and/or perinatal health (e.g., preterm birth, elevated
maternal blood pressure, perinatal mood and anxiety) in the study population? (4) How do resilience and risk
factors in the context of the COVID-19 pandemic (e.g., perceived coping, economic stress, food/housing
insecurity, death of partner, domestic violence) affect perinatal health outcomes in this study population? To
answer these questions, we will add to the research team an expert in SRD and perinatal mental health; an
expert in trauma and resilience; and two Consultants/ Community Partners to enhance community-
engagement and address key issues of recruitment, retention, and structural bias in research with
underserved, minority populations. We will use common data elements (e.g., DR2, PhenX toolkit) for future
data harmonization, in order to contribute to knowledge about behavioral, sociocultural, and structural factors
that affect pregnancy-related morbidity/mortality and maternal-child health in the context of the pandemic.
项目摘要-妈妈咪啊研究行政补充(1R01HD100395-01; PI:
项目成果
期刊论文数量(0)
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Patricia Anne Kinser其他文献
Patricia Anne Kinser的其他文献
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{{ truncateString('Patricia Anne Kinser', 18)}}的其他基金
Community-based fetal ultrasound and care navigation: An approach to engaging pregnant women with substance use disorder in prenatal care and substance use treatment
基于社区的胎儿超声和护理导航:一种让患有物质使用障碍的孕妇参与产前护理和物质使用治疗的方法
- 批准号:
10649029 - 财政年份:2022
- 资助金额:
$ 25.17万 - 项目类别:
Community-based fetal ultrasound and care navigation: An approach to engaging pregnant women with substance use disorder in prenatal care and substance use treatment
基于社区的胎儿超声和护理导航:一种让患有物质使用障碍的孕妇参与产前护理和物质使用治疗的方法
- 批准号:
10709656 - 财政年份:2022
- 资助金额:
$ 25.17万 - 项目类别:
A multisite randomized controlled trial of an internet-based program for preventing and reducing perinatal depressive symptoms
基于互联网的预防和减少围产期抑郁症状项目的多中心随机对照试验
- 批准号:
10600852 - 财政年份:2020
- 资助金额:
$ 25.17万 - 项目类别:
A multisite randomized controlled trial of an internet-based program for preventing and reducing perinatal depressive symptoms
基于互联网的预防和减少围产期抑郁症状项目的多中心随机对照试验
- 批准号:
10376811 - 财政年份:2020
- 资助金额:
$ 25.17万 - 项目类别:
Self-Management of Chronic Depressive Symptoms in Pregnancy
妊娠期慢性抑郁症状的自我管理
- 批准号:
9095673 - 财政年份:2016
- 资助金额:
$ 25.17万 - 项目类别:
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