Purification, structure characterization of bioactive substances from marine organisms and application them to the novel targeting oral cancer drugs
Purification, structure characterization of bioactive substances from marine organisms and application them to the novel targeting oral cancer drugs
海洋生物活性物质的纯化、结构表征及其在口腔癌新型靶向药物中的应用
批准号：
23592962
负责人：
YUKIO YOSHIOKA
金额：
$3.24万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2013
中文摘要
翻译
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英文摘要
Marine organisms from Japanese adjacent Sea is collected and freeze-dried. They are homogenized in EtOH-MeOH(4:1)and distributed by HPLC into hexane layer and C2H5OCH3CO layer and aqueous layer. Following it, the extracted compounds are investigated their activity by bio-assay and are purified and decided their structure by LC/MS. Their analogues improving the structure of their branches are produced and massively synthesized them. The anti-tumor activity is investigated by the inoculated tumor cell on nude mouse. CD133 is a useful marker of the oral squamous cell carcinoma cells. The oral cancer stem cells were isolated from the oral squamous cell carcinoma cell line with index of CD133 and analyzed the character of a stem cell. The mechanism of the novel anti-tumor agents against not only the oral cancer but also the oral cancer stem cells is analyzed in vitro.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ビスフォスフォネート関連顎骨壊死にて腐骨除去術を行い長期観察し得た骨Paget病の１例
佩吉特骨病一例，其中双磷酸盐相关的颌骨坏死通过牺牲骨去除进行治疗，并且可以进行长期观察。
佩吉特骨病一例，其中双磷酸盐相关的颌骨坏死通过牺牲骨去除进行治疗，并且可以进行长期观察。
DOI：
--
发表时间：
2012
期刊：
日本口腔科学会雑誌
影响因子：
--
作者：
[Tanaka T, Nakayama H, Yoshitake Y, Irie A, Nagata M, Kawahara K, Takamune Y, Yoshida R, Nakagawa Y, Ogi H, Shinriki S, Ota K, Hiraki A, Ikebe T, Nishimura Y, Shinohara M, 吉岡幸男 虎谷茂昭 向笠英恵 神田拓 新谷智章 岡本哲治]
通讯作者：
吉岡幸男 虎谷茂昭 向笠英恵 神田拓 新谷智章 岡本哲治
DOI：
10.1016/j.tet.2012.10.063
发表时间：
2013-01-07
期刊：
TETRAHEDRON
影响因子：
2.1
作者：
[Horikawa, Kouhei, Yagyu, Takuya, Ojika, Makoto]
通讯作者：
Ojika, Makoto
海外基金
