The role of miRNA on the mechanism of metastasis induced by the SDF-1/CXCR4 system in oral cancer

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We examined the microRNA downstream of CXCR4 system that is one of a metastatic system in oral cancer. We identified the upregulation of miR-518c-5p, which is reported as an oncomiR in bladder cancer. A miR-518c-5p inhibitor significantly inhibited the CXCR4 system-dependent migration of oral cancer cells. The growth and migration of B88-518c cells, transfected by the miR-518c expression vector, were significantly enhanced. Furthermore, tumor volume, lymph nodes metastasis, and lung metastasis were significantly increased in the nude mice inoculated with B88-518c cells. These results indicated that miR-518c-5p regulates the metastases of oral cancer as a downstream target of CXCR4 system.