Development of the inhibition therapy against growth and metastasis of oral cancer targeting CXC chemokine, SDF-1

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We have tried to inhibit both growth via CXCR7 and metastasis via CXCR4 by the inhibition of SDF-1 on the oral cancer cells. SDF-l antibody inhibited the anchorage independent growth of oral cancer cells in vitro, but did affect neither growth nor metastasis in vivo. However, a CXCR4 specific antagonist AMD3100 significantly inhibited the metastasis of oral cancer cells. These results indicated that inhibition of both CXCR4 and CXCR7 by the SDF-1 antibody is difficult, but AMD3100 may be a potent anti-metastatic therapy in cases of CXCR4-related oral cancer.