Development of the inhibition therapy against growth and metastasis of oral cancer targeting CXC chemokine, SDF-1

开发针对CXC趋化因子SDF-1的口腔癌生长和转移抑制疗法

• 批准号: 21792003
• 负责人: UCHIDA Daisuke
• 金额: $ 2.75万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21792003/
• 关键词: SDF-1; CXCR4; 口腔癌; 転移; CXCR7; AMD3100

We have tried to inhibit both growth via CXCR7 and metastasis via CXCR4 by the inhibition of SDF-1 on the oral cancer cells. SDF-l antibody inhibited the anchorage independent growth of oral cancer cells in vitro, but did affect neither growth nor metastasis in vivo. However, a CXCR4 specific antagonist AMD3100 significantly inhibited the metastasis of oral cancer cells. These results indicated that inhibition of both CXCR4 and CXCR7 by the SDF-1 antibody is difficult, but AMD3100 may be a potent anti-metastatic therapy in cases of CXCR4-related oral cancer.

我们已经尝试通过抑制口腔癌细胞上的SDF-1来抑制经由CXCR 7的生长和经由CXCR 4的转移。SDF-1抗体在体外抑制口腔癌细胞的贴壁非依赖性生长，但在体内不影响口腔癌细胞的生长和转移。然而，CXCR 4特异性拮抗剂AMD 3100显著抑制口腔癌细胞的转移。这些结果表明，SDF-1抗体难以抑制CXCR 4和CXCR 7，但AMD 3100可能是CXCR 4相关口腔癌病例的有效抗转移治疗。

项目成果

ケモカインレセプターCXCR4を介した唾液腺腺様嚢胞癌の転移機構

趋化因子受体CXCR4介导的唾液腺腺样囊性癌转移机制

• 发表时间: 2009
• 作者: 内田大亮;他
• 通讯作者: 他

Blockade of CXCR4 in oral squamous cell carcinoma inhibits lymph node metastases

• DOI: 10.1016/j.ejca.2010.09.028
• 发表时间: 2011-02-01
• 期刊: EUROPEAN JOURNAL OF CANCER
• 影响因子: 8.4
• 作者: Uchida, Daisuke;Onoue, Tomitaro;Miyamoto, Youji
• 通讯作者: Miyamoto, Youji

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Vesnarinone downregulates CXCR4 expression via upregulation of Kruppel-like factor 2 in oral cancer cells

• DOI: 10.1186/1476-4598-8-62
• 发表时间: 2009-08-12
• 期刊: MOLECULAR CANCER
• 影响因子: 37.3
• 作者: Uchida, Daisuke;Onoue, Tomitaro;Miyamoto, Youji
• 通讯作者: Miyamoto, Youji