Effect of dental pulp stem cells for the peripheral nerve paralysis

通过对大鼠坐骨神经损伤模型的形态学分析，证明牙髓干细胞移植促进了周围神经损伤的愈合。牙髓干细胞(DPSCs)在体内和体外表达多种神经营养因子和血管生成因子。此外，在体内未见DPSCs直接分化为雪旺细胞。移植的DPSCs定位于残留雪旺细胞附近。因此，这些结果提示DPSCS对残留/新迁移的雪旺细胞具有营养作用，包括促进雪旺细胞的增殖和趋化作用，以及抗邻近细胞的凋亡。

We demonstrated that transplantation of dental pulp stem cells accelerated the healing of the injured peripheral nerve in the rat sciatic nerve defect model by morphological analyses. Dental pulp stem cells (DPSCs) expressed several neurotrophic/angiogenic factors both in vivo and in vitro. In addition, direct differentiation of DPSCs into Schwann cells was not shown in vivo. Transplanted DPSCs localized in the vicinity of the residual Schwann cells. Thus, these results suggest trophic effect of DPSCs on remaining/newly migrated Schwann cells, including enhanced proliferation and chemotaxis of Schwann cells and anti-apoptosis of adjacent cells.