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An in vitro model of cartilage degradation by chondrocytes in a three-dimensional culture system

An in vitro model of cartilage degradation by chondrocytes in a three-dimensional culture system
三维培养系统中软骨细胞降解软骨的体外模型
批准号:
19592328
负责人:
KURITA Kenichi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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项目成果

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中文摘要
翻译
本研究结果提示,TIMP-1在早期预防关节软骨破坏中起主要作用,但TIMP-3逐渐取代这一作用。此外,转化生长因子-β被证明调节这些TIMP,并作为关节软骨破坏的抑制者。这些结果表明,TIMP-1和TIMP-3在预防关节疾病(如骨关节炎)的进展中密切相关。
英文摘要
The results of this study suggest that TIMP-1 plays a primary role in the prevention of articular cartilage destruction in its early stage but that TIMP-3 gradually takes over this role. Also, TGF-β was shown to regulate these TIMPs and act as a suppressor of articular cartilage destruction. These results suggest that TIMP-1 and TIMP-3 are closely involved in preventing the progression of joint disorders such as OA.
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Effect of dental pulp stem cells for the peripheral nerve paralysis
  • 批准号:
    23593007
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.41万
  • 财政年份:
    2011
  • 负责人:
    KURITA Kenichi
  • 依托单位:
Pathologic Studies on Induction of Craniomandibular Joint Arthritis is using in Rabbits Escherichia Coli Antigens
INTRACAPSULAR PATHOLOGICAL PROCESS CAUSED BY TMJ DISK DISPLACEMNT IN SHEEP
Diagnostic Accuracy of the Ultrathin Arthroscope for Temporomandibular Joint Osteoarthrosis : Comparison of Arthroscopic and Histologic Findings in a Sheep Model.
  • 批准号:
    05671695
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)
  • 资助金额:
    $0.9万
  • 财政年份:
    1993
  • 负责人:
    KURITA Kenichi
  • 依托单位:
国内基金
海外基金
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    2026
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细菌纤维素复合敷料的电响应设计及其调控创面MMP-9/TIMP-1 通路促烧伤创面愈合机制研究
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    吴迎
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固本消积颗粒通过TIMP-1抑制SDF-1/CXCR3依赖性中性粒细胞募集重塑CRC肝前转移生态位的临床及基础研究
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