An in vitro model of cartilage degradation by chondrocytes in a three-dimensional culture system

三维培养系统中软骨细胞降解软骨的体外模型

• 批准号: 19592328
• 负责人: KURITA Kenichi
• 金额: $ 2.83万
• 依托单位: Aichi Gakuin University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592328/
• 关键词: 軟骨; TIMP; CAM; Alginate beads; ECM; IL-1β; TGF-β; OA; HA

The results of this study suggest that TIMP-1 plays a primary role in the prevention of articular cartilage destruction in its early stage but that TIMP-3 gradually takes over this role. Also, TGF-β was shown to regulate these TIMPs and act as a suppressor of articular cartilage destruction. These results suggest that TIMP-1 and TIMP-3 are closely involved in preventing the progression of joint disorders such as OA.

这项研究的结果表明，TIMP-1在早期阶段的关节软骨破坏的预防中起主要作用，但TIMP-3逐渐接管了这一作用。此外，TGF-β被证明可以调节这些TIMP，并作为关节软骨破坏的抑制剂。这些结果表明，TIMP-1和TIMP-3密切参与预防关节疾病如OA的进展。